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Structure and Localization of Glycoproteins and Proteoglycans

  • Renée K. Margolis
  • Richard U. Margolis

Abstract

Glycosaminoglycans are high-molecular-weight linear carbohydrate polymers that are generally composed of disaccharide repeating units of a uronic acid (D-glucuronic acid or L-iduronic acid) and a hexosamine (G1cNAc or GaINAc). Chondroitin sulfate and heparan sulfate occur as proteoglycans in which the polysaccharide chains are covalently linked at their reducing ends to the hydroxyl groups of serine residues in a protein moiety.

Keywords

Hyaluronic Acid Sialic Acid Heparan Sulfate Chondroitin Sulfate Sulfate Proteoglycan 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations used in this chapter

Con A

concanavalin A

NGF

nerve growth factor

NILE

NGFinducible large external glycoprotein

AcNeu

N-acetylneuraminic acid

Fuc

l-fucose

Gal

d-galactose

Ga1NAc

n-acetyl-d-galac-tosamine

GlcNAcol

n-acetyl-d-glucosaminitol

GaINAcol

n-acetyl-d-galactosaminitol

GcNeu

n-glycolylneuraminic acid

Glc

d-glucose

GlcNAc

n-acetyl-d-glucosamine

Man

d-mannose

Manol

mannitol

DBH

dopamine β-hydroxylase

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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Renée K. Margolis
    • 1
  • Richard U. Margolis
    • 2
  1. 1.Department of PharmacologyState University of New York, Health Science Center at BrooklynBrooklynUSA
  2. 2.Department of PharmacologyNew York University Medical CenterNew YorkUSA

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