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Synaptic Vesicle Glycoproteins and Proteoglycans

  • Chapter
Neurobiology of Glycoconjugates

Abstract

Immunological markers specific for synaptic vesicles have been helpful in studying synapse regeneration (Glicksman and Sanes, 1983), development (Chun and Shatz, 1983), and tracing membrane traffic in the nerve terminal (von Wedel et al., 1981). Vesicle-specific antibodies have also identified a number of vesicle proteins. This chapter deals with four antigenic integral membrane proteins of the synaptic vesicle. These proteins, identified with monoclonal antibodies, are the best characterized vesicle membrane components. Three of these proteins are probably present in all vesicles of the regulated pathway of neuroendocrine cells. This includes both dense-core vesicles and small, clear synaptic vesicles. The cDNA for one of these proteins, p38, has been cloned and sequenced. The fourth protein is an integral membrane proteoglycan (SVPG) which has been found in some synaptic vesicles, but could have a wider distribution. Interestingly, this proteoglycan shares a unique antigenic site with a putative nerve terminal anchorage protein, TAP-1.

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  1. Department of Physiology and Biophysics, University of Washington, Seattle, Washington, 98195, USA

    Steven S. Carlson

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  1. Steven S. Carlson
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  1. Department of Pharmacology, New York University Medical Center, 10016, New York, New York, USA

    Richard U. Margolis

  2. Department of Pharmacology, State University of New York, Health Science Center at Brooklyn, 11203, Brooklyn, New York, USA

    Renée K. Margolis

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Carlson, S.S. (1989). Synaptic Vesicle Glycoproteins and Proteoglycans. In: Margolis, R.U., Margolis, R.K. (eds) Neurobiology of Glycoconjugates. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5955-6_10

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