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Oxidative Stress and Thymocyte Apoptosis

  • Noriko Tonomura
  • Richard A. Goldsby
  • Eric V. Granowitz
  • Barbara Osborne
Chapter

Abstract

Mitochondria play a major role in making decisions in programmed cell death. During thymocyte apoptosis, the function of mitochondrial electron transport chain becomes pro-apoptotic and produces increased levels of reactive oxygen species (ROS). The resulting oxidative stress can further aggravate apoptotic events, leading thymocytes to death. The site of ROS production during thymocyte apoptosis is most likely at complex III of the electron transport chain, and the pro-apoptotic function of electron transport chain is regulated by the proteasome.

Keywords

Electron Transport Chain Proteasome Activity Mitochondrial Electron Transport Chain Mitochondrial Membrane Permeabilization Cell Death Differ 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Noriko Tonomura
    • 1
    • 2
  • Richard A. Goldsby
    • 3
  • Eric V. Granowitz
    • 4
    • 5
  • Barbara Osborne
    • 1
    • 2
  1. 1.Transplantation Biology Research CenterMassachusetts General Hospital, Harvard Medical SchoolBostonUSA
  2. 2.The Program in Molecular and Cellular BiologyUniversity of MassachusettsAmherstUSA
  3. 3.Department of BiologyAmherst CollegeAmherstUSA
  4. 4.Department of MedicineBaystate Medical CenterSpringfieldUSA
  5. 5.Tufts University School of MedicineBostonUSA

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