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The Mechanism of Apoptosis Regulation by IAP Antagonist Smac/DIABLO

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Molecular Mechanisms of Programmed Cell Death

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Abstract

Caspases are central components of the machinery responsible for cell apoptosis. The inhibitor of apoptosis proteins (IAPs) could efficiently block the caspases activation. Recently, a novel cell death regulator Smac/DIABLO (second mitochondria derived activator of caspases/Direct IAP Binding protein with low PI) was identified. Smac/DIABLO performs a critical function in apoptosis by eliminating the inhibition of IAPs. This article will firstly review the role of caspases and IAPs in apoptosis and then focus on the mechanism of apoptosis regulation by IAP antagonist Smac. We will discuss what is currently known about Smac/DIABLO such as the structure and function of Smac/DIABLO in apoptosis; its relation with Bd-2 family proteins as well as its potenial application in cancer therapy.

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Authors and Affiliations

  1. Shanghai International Joint Cancer Institute, The Second Military Medical University, Shanghai, 200433, China

    Dr. Yajun Guo

  2. Eppley Cancer Institute, Omaha, NE, 68198, USA

    Dr. Yajun Guo

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  1. Jun Jin
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  2. Jianxin Dai
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  3. Jian Zhao
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Correspondence to Yajun Guo .

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Editors and Affiliations

  1. Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey, USA

    Yufang Shi

  2. National Institutes of Health, Research Triangle Park, North Carolina, USA

    John A. Cidlowski

  3. American Red Cross, Rockville, Maryland, USA

    David Scott

  4. Chinese Academy of Sciences, Shanghai, China

    Jia-Rui Wu

  5. National Institutes of Health, Bethesda, Maryland, USA

    Yun-Bo Shi

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Jin, J., Dai, J., Zhao, J., Guo, Y. (2003). The Mechanism of Apoptosis Regulation by IAP Antagonist Smac/DIABLO. In: Shi, Y., Cidlowski, J.A., Scott, D., Wu, JR., Shi, YB. (eds) Molecular Mechanisms of Programmed Cell Death. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5890-0_17

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  • DOI: https://doi.org/10.1007/978-1-4757-5890-0_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4419-3404-8

  • Online ISBN: 978-1-4757-5890-0

  • eBook Packages: Springer Book Archive

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