Abstract
Reactive gliosis, leading to the formation of glial scar, is the response of astrocytes to CNS injury. It is an ubiquitous reaction observed in a large number of pathological conditions, such as mechanical and chemical lesions, as well as degenerative processes (Fulcrand and Privat, 1977; Eng and De Armond, 1982). This reaction is twofold, being characterized by an astrocyte multiplication (hyperplasia) as well as an hypertrophy of the perikarya and processes (Hain et al., 1960; Nathaniel and Nathaniel, 1981). The main intracellular event is an increase of the number of gliafilaments, paralleled by a raise in GFAP immunoreactivity.
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Rataboul, P., Vernier, P., Privat, A. (1990). Analysis of Glial Scarring in the Mammalian CNS with a GFAP cDNA Probe. In: Lauder, J.M., Privat, A., Giacobini, E., Timiras, P.S., Vernadakis, A. (eds) Molecular Aspects of Development and Aging of the Nervous System. Advances in Experimental Medicine and Biology, vol 265. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5876-4_3
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DOI: https://doi.org/10.1007/978-1-4757-5876-4_3
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