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Localization of the Normal Cellular SRC Protein to the Growth Cone of Differentiating Neurons in Brain and Retina

  • Patricia F. Maness
  • Carol G. Shores
  • Michael Ignelzi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 265)

Abstract

The protooncogene c-src is implicated in the development of the vertebrate nervous system. Its product pp60c-src is a tyrosine-specific protein kinase that is expressed in two phases of neural development. An activated form of the pp60c-src is highly enriched in the membrane of nerve growth cones and in the proximal neuritic shaft of differentiating neurons, as shown in brain and retina. A possible role for pp60c-src in neuronal process extension is suggested that may involve cell-substratum adhesion or motility.

Keywords

Chick Embryo Growth Cone Optic Tectum Retinal Neuron Neural Retina 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Patricia F. Maness
    • 1
  • Carol G. Shores
    • 1
  • Michael Ignelzi
    • 1
  1. 1.Department of BiochemistryUniversity of North Carolina School of MedicineChapel HillUSA

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