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Neuropeptides and the Control of Egg-laying Behavior in Aplysia

  • Earl Mayeri
  • Barry S. Rothman

Abstract

The marine mollusk Aplysia is proving to be a useful experimental system for studying the roles of neuropeptides in neuronal function and their roles in the neural regulation of behavior. The main emphasis of investigations in our laboratory has been on the bag cell system, a group of peptide-secreting neuroendocrine cells that induce egg laying in Aplysia and also have profound effects on other central neurons.

Keywords

Burst Discharge Bathing Medium Abdominal Ganglion Atrial Gland Transient Excitation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Arch, S., 1976, Biochemical isolation and physiological identification of the egg laying hormone in Aplysia californica, J. Gen. Physiol. 68:197–210.PubMedCrossRefGoogle Scholar
  2. Arch, S., and Smock, T., 1977, Egg laying behavior in Aplysia californica, Behav. Biol. 19:45–54.CrossRefGoogle Scholar
  3. Arch, S., Smock, T., Gurvis, R., and McCarthy, C, 1978, Atrial gland induction of the egg-laying response in Aplysia californica, J. Comp. Physiol. A128:67–70.CrossRefGoogle Scholar
  4. Arch, S., Lupatkin, J., Smock, T., and Beard, M., 1980, Evidence for an exocrine function of the Aplysia atrial gland, J. Comp. Physiol. A141:131–137.CrossRefGoogle Scholar
  5. Berry, R. W., 1981, Proteolytic processing in the biogenesis of the neurosecretory egg-laying hormone in Aplysia. 1. Precursors, intermediates and products, Biochemistry 20:6200–6205.PubMedCrossRefGoogle Scholar
  6. Blankenship, J. E., and Haskins, J. T., 1979, Electrotonic coupling among neuroendocrine cells in Aplysia, J. Neurophysiol. 42:347–355.PubMedGoogle Scholar
  7. Branton, W. D., Mayeri, E., Brownell, P., and Simon, S. B., 1978a, Evidence for local hormonal communication between neurones in Aplysia, Nature (London) 274:70–72.CrossRefGoogle Scholar
  8. Branton, W. D., Arch, S., Smock, T., and Mayeri, E., 1978b, Evidence for mediation of a neuronal interaction by a behaviorally active peptide, Proc. Natl. Acad. Sci. U.S.A. 75:5732–5736.PubMedCrossRefGoogle Scholar
  9. Brownell, P., and Mayeri, E., 1979, Prolonged inhibition of neurons by neuroendocrine cells in Aplysia, Science 204:417–420.PubMedCrossRefGoogle Scholar
  10. Brownell, P. H., and Schaefer, M. E., 1982, Activation of a long-lasting motor program by bag cell neurons in Aplysia, Neurosci. Abstr. 8:736.Google Scholar
  11. Chiu, A. Y., and Strumwasser, F., 1981, An immunohistochemical study of the neuropeptide bag cells of Aplysia, J. Neurosci. 1:812–826.PubMedGoogle Scholar
  12. Chiu, A. Y., Hunkapiller, M. W., Heller, E., Stuart, D. K., Hood, L. E., and Strumwasser, F., 1979, Purification and primary structure of the neuropeptide egg-laying hormone of Aplysia californica, Proc. Natl. Acad. Sci. U.S.A. 76:6656–6660.PubMedCrossRefGoogle Scholar
  13. Cobbs, J. S., and Pinsker, H. M., 1982a, Role of bag cells in egg deposition of Aplysia brazilliana. I. Comparison of normal and elicited behaviors, J. Comp. Physiol. 147:523–535.CrossRefGoogle Scholar
  14. Cobbs, J. S., and Pinsker, H. M., 1982b, Role of bag cells in egg deposition of Aplysia braziliana. II. Contribution of egg movement to elicited behaviors J. Comp. Physiol. 147:537–546.CrossRefGoogle Scholar
  15. Dale, H. H., Feldberg, W., and Vogt, M., 1936, Release of acetylcholine at voluntary motor nerve endings J. Physiol. 86:353–380.PubMedGoogle Scholar
  16. Dismukes, R. K., 1979, New concepts of molecular communication among neurons, Behav. Brain Sci. 2:409–448.CrossRefGoogle Scholar
  17. Frazier, W. T., Kandel, E. R., Kupfermann, I., Waziri, R., and Coggeshall, R. E. 1967, Morphological and functional properties of identified neurons in the abdominal ganglion of Aplysia californica, J. Neurophysiol. 30:1288–1351.Google Scholar
  18. Gainer, H., Loh, Y. P., and Same, J. Y., 1977, Biosynthesis of neuronal peptides, in: Peptides in Neurobiology (H. Gainer, ed.), Plenum Press, New York, pp. 183–219.CrossRefGoogle Scholar
  19. Glitsch, H. G., and Pott, L., 1978, Effects of acetylcholine and parasympathetic nerve stimulation on membrane potential in quiescent guinea-pig atria J. Physiol. 279:655–668.PubMedGoogle Scholar
  20. Hartzell, H. C, Kuffler, S. W., and Yoshikami, D., 1975, Postsynaptic potentiation: Interaction between quanta of acetylcholine at the skeletal neuromuscular synapse J. Physiol. (London) 251:427.Google Scholar
  21. Haskins, J. T., Price, C. H., and Blankenship, J. E., 1981, A light and electron microscope investigation of the neurosecretory bag cells of Aplysia, J. Neurocytol. 10:729–747.PubMedCrossRefGoogle Scholar
  22. Heller, E., Kaczmarek, L. K., Hunkapiller, M. W., Hood, L. E., and Strumwasser, F., 1980, Purification and primary structure of two neuroactive peptides that cause bag cell afterdischarge and egg-laying in Aplysia, Proc. Natl. Acad. Sci. U.S.A. 77:2328–2332.PubMedCrossRefGoogle Scholar
  23. Herbert, E., Birnberg, N., Lissitsky, J-C., Ciuelli, O., and Uhler, M., 1981, Proopiomelanocortin: A model for the regulation of expression of neuropeptides in pituitary and brain, Neurosci. Comment. 1:16–27.Google Scholar
  24. Kandel, E. R., 1976, Cellular Basis of Behavior, Freeman, San Francisco, California.Google Scholar
  25. Kupfermann, I., 1967, Stimulation of egg laying: Possible neuroendocrine function of bag cells of abdominal ganglion of Aplysia californica, Nature (London) 216:814–815.CrossRefGoogle Scholar
  26. Kupfermann, I., and Kandel, E. R., 1970, Electrophysiological properties and functional interconnections of two symmetrical neurosecretory clusters (bag cells) in abdominal ganglion of Aplysia, J. Neurophysiol. 33:865–876.PubMedGoogle Scholar
  27. Loewi, O., 1921, Uber humorale Ubertragbarkeit der Herznerven Wirkung. I. Mitteilung Pflueger s Arch. Ges. Physiol. 189:239–242.CrossRefGoogle Scholar
  28. Mayeri, E., 1979, Local hormonal modulation of neural activity in Aplysia, (FASEB Symposium on “Modulation of Synaptic Excitability”), Fed. Proc. 38:2103–2108.PubMedGoogle Scholar
  29. Mayeri, E., and Rothman, B. S., 1982a, Nonsynaptic peptidergic neurotransmission in the abdominal ganglion of Aplysia, in: Neurosecretion—Molecules, Cells and Systems (D. S. Farner and K. Lederis, eds.), Plenum Press, New York, pp. 307–318.Google Scholar
  30. Mayeri, E., and Rothman, B. S., 1982b, Peptide effects on mollusckan neurons, in: Strategies for Studying the Roles of Peptides in Neuronal Function (J. L. Barker, ed.), Short Course Syllabus, Society for Neuroscience, Bethesda, Maryland, pp. 121–130.Google Scholar
  31. Mayeri, E., and Simon, S., 1975, Modulation of synaptic transmission and burster neuron activity after release of a neurohormone in Aplysia, Neurosci. Abstr. 1:584.Google Scholar
  32. Mayeri, E., Brownell, P. H., Branton, W. D., and Simon, S. B., 1979a, Multiple, prolonged actions of neuroendocrine bag cells on neurons in Aplysia. I. Effects on bursting pacemaker neurons, J. Neurophysiol. 42:1165–1184.PubMedGoogle Scholar
  33. Mayeri, E., Brownell, P. H., and Branton, W. D., 1979b, Multiple, prolonged actions of neuroendocrine bag cells on neurons in Aplysia. II. Effects on beating pacemaker and silent neurons, J. Neurophysiol. 42:1185–1197.PubMedGoogle Scholar
  34. Mayeri, E., Rothman, B. S., Brownell, P., Branton, W. D., and Padgett, L., 1985, Nonsynaptic characteristics of neurotransmission mediated by ELH in the abdominal ganglion of Aplysia, f. Neurosci. (in press).Google Scholar
  35. Pinsker, H. M., and Dudek, F. E., 1977, Bag cell control of egg-laying in freely-behaving Aplysia, Science 197:490–493.PubMedCrossRefGoogle Scholar
  36. Rothman, B. S., Brown, R. O., Mayeri, E., and Shively, J. E., 1982, Isolation of novel, neuroactive ELH-like peptides from the atrial gland of Aplysia, Soc. Neurosci. Abstr. 8:14.Google Scholar
  37. Rothman, B. S., Mayeri, E., and Scheller, R. H., 1984, The bag cell neurons of Aplysia as a possible peptidergic multitransmitter system: From genes to behavior, in: Gene Expression in Brain (C. Zomzely-Neurath and W. A. Walker, eds.), Wiley and Sons, New York.Google Scholar
  38. Rothman, B. S., Weir, G., and Dudek, F. E., 1983b, Egg-laying hormone: Direct action on the ovotesis of Aplysia, Gen. Comp. Endocrinol. 52:134–141.PubMedCrossRefGoogle Scholar
  39. Rothman, B. S., Mayeri, E., and Scheller, R. H., 1984, The bag cell neurons of Aplysia as a possible peptidergic multitransmitter system: From genes to behavior, in: Gene Expression in Brain (C. Zomzely-Neurath and W. A. Walker, eds.), Wiley and Sons, New York.Google Scholar
  40. Scheller, R. H., Jackson, J. F., McAllister, L. B., Schwartz, J. H., Kandel, E. R., and Axel, R., 1982, A family of genes that codes for ELH, a neuropeptide eliciting a stereotyped pattern of behavior in Aplysia, Cell 28:707–719.CrossRefGoogle Scholar
  41. Scheller, R. H., Jackson, J. F., McAllister, L. B., Rothman, B. S., Mayeri, E., and Axel, R., 1983a, A single gene encodes multiple neuropeptides mediating a stereotyped behavior, Cell 32:7–22.PubMedCrossRefGoogle Scholar
  42. Scheller, R. H., Rothman, B. S., and Mayeri, E., 1983b, A single gene encodes multiple peptide neurotransmitter candidates involved in a stereotyped behavior, Trends Neurosci. 6:340–345.CrossRefGoogle Scholar
  43. Sigvardt, K., Rothman, B. S., and Mayeri, E., 1983, Analysis of inhibition produced by the candidate neurotransmitter, α-bag cell peptide, in identified neurons of Aplysia, Soc. Neurosci. Abstr. 9:311.Google Scholar
  44. Sigvardt, K. A., Rothman, B. S., Brown, R. O., and Mayeri, E., 1984, The bag cells of Aplysia as a multitransmitter system: identification of alpha bag cell peptide as a second neurotransmitter (submitted).Google Scholar
  45. Stuart, D. K., and Strumwasser, F., 1980, Neuronal sites of action of a neurosecretory peptide, egg-laying hormone, in Aplysia californica, J. Neurophysiol. 43:499–519.PubMedGoogle Scholar
  46. Tinbergen, N., 1951, The Study of Instinct, Oxford University Press, New York.Google Scholar

Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • Earl Mayeri
    • 1
  • Barry S. Rothman
    • 1
  1. 1.Department of PhysiologyUniversity of CaliforniaSan FranciscoUSA

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