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Phospholipid Exchange between Membranes

  • D. B. Zilversmit
  • M. E. Hughes

Abstract

Exchange of phospholipids between serum lipoproteins was described more than 20 years ago by Eder et al. (1954) and by Kunkel and Beam (1954). A few years later, Florsheim and Morton (1957) showed that phospholipid exchange between serum lipoprotein fractions is rapid compared to the disappearance of these lipids from plasma. Exchange of phospholipids between chylomicrons and higher density serum lipoprotein was demonstrated by McCandless and Zilversmit (1958). These studies were extended by Minari and Zilversmit (1963), who showed that the loss of labeled phospholipids from chylomicrons incubated with dog serum was increased greatly when the proportion of serum phospholipid to chylomicron phospholipid was increased approximately tenfold (Fig. 1). In the same study, it was demonstrated that phospholipids exchanged between chylomicrons and serum lipoproteins but that the movement from chylomicrons to serum was greater than that in the reverse direction, thus leading to a net loss of phospholipid from the chylomicron fraction. The relation of this transfer to the removal of chylomicrons from the circulation has been discussed by Zilversmit (1969).

Keywords

Exchange Protein Beef Heart Cholesteryl Oleate Beef Liver Transposition Rate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • D. B. Zilversmit
    • 1
  • M. E. Hughes
    • 1
  1. 1.Division of Nutritional Sciences and Section of Biochemistry Molecular and Cell Biology, Division of Biological SciencesCornell UniversityIthacaUSA

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