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Membrane Lipid Homeostasis

  • Claude Wolf
  • Peter J. Quinn
Part of the Subcellular Biochemistry book series (SCBI, volume 37)

Abstract

The lipid matrix of biological membranes is composed of a complex mixture of polar lipids. It has been estimated that more than 600 distinct molecular species of lipid are constituents of biological membranes. This rather remarkable feature raises the questions of why such complexity is required when barrier properties and many protein functions can be reconstituted with relatively simple lipid systems. Secondly, the molecular species composition of morphologically distinct membranes appears to be preserved within fairly narrow limits. The biochemical mechanism(s) responsible for this homeostasis are not fully understood. This review examines the origin of membrane lipid complexity, the methods that are currently employed to measure and detect lipid molecular species and the biochemical reactions associated with the turnover of membrane lipids in resting and stimulated cells.

Keywords

Membrane Lipid Molecular Species Lipid Class Phorbol Myristate Acetate Outer Leaflet 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2004

Authors and Affiliations

  • Claude Wolf
    • 1
  • Peter J. Quinn
    • 2
  1. 1.Biochemistry Department, Mass Spectrometry Laboratory, INSERM U. 538Faculté de Médecine Saint AntoineParisFrance
  2. 2.Life Sciences Department, BiochemistryKing’s College LondonLondonUK

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