Structure-Function Relationships for High and Low-Affinity Interleukin 2 Receptors
The original study of interleukin 2 (IL-2) binding to activated lymphocytes by Robb and colleagues1 described a high-affinity receptor-ligand association which fit nicely with the very low levels of IL-2 which promoted cellular proliferation. Later studies, however, demonstrated that the IL-2 receptor actually existed in a number of forms with drastically different affinities for ligand2. Our subsequent research has focused on explaining these differences in molecular terms and relating them to the function of this versatile growth and differentiation factor. Insight into structure-function relationships for the IL-2-receptor system should prove particularly valuable to the design of drugs which can be used to manipulate IL-2-dependent immunological responses.
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