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Structure and Regulation of the Human IL-2 Receptor

  • Warner C. Greene
  • Ernst Böhnlein
  • Miriam Siekevitz
  • Dean W. Ballard
  • B. Robert Franza
  • John W. Lowenthal

Abstract

The growth of human T lymphocytes can be divided into two discrete stages resembling competence and progression. In the first stage, the binding of antigen or mitogen to specific T cell receptors triggers the transduction of intracellular signals leading to cellular activation1,2. In turn, these activation signals induce the de novo expression of genes mediating T cell growth including interleukin-2 (IL-2) and interleukin-2 receptors (IL-2R)3–5. The subsequent binding of IL-2 to its high affinity receptor promotes proliferation and clonal expansion of the cells originally stimulated by antigen.

Keywords

Human Immunodeficiency Virus Jurkat Cell Thymidine Kinase Promoter Intermediate Affinity Kappa Light Chain Immunoglobulin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Warner C. Greene
    • 1
  • Ernst Böhnlein
    • 1
  • Miriam Siekevitz
    • 2
  • Dean W. Ballard
    • 1
  • B. Robert Franza
    • 3
  • John W. Lowenthal
    • 1
  1. 1.Howard Hughes Medical InstituteDuke University Medical CenterDurhamUSA
  2. 2.Mt. Sinai Medical CenterNew YorkUSA
  3. 3.Cold Spring Harbor LaboratoryCold Spring HarborUSA

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