Use of Somatic Cell Mutants to Study the Signal Transduction Function of the T Cell Antigen Receptor
The activation of thymus-derived lymphocytes (T cells) is regulated by cell surface molecules that may function in a stimulatory or inhibitory manner. Among the many plasma membrane proteins that have been implicated in T cell functional activities, the antigen receptor plays a central role in initiating T cell activation during an immune response. Upon appropriate interaction with antigen or anti-receptor antibodies that have been used to mimic antigen, the T cell receptor induces transmembrane signalling events that contribute to the subsequent cellular response. Such cellular activation is most commonly manifested by the appearance of cytolytic activity, production of lymphokines or proliferation of T cells.
KeywordsJurkat Cell Phorbol Myristate Acetate Antigen Receptor Inositol Phosphate Transmembrane Signalling
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