Application of Cox Regression with a Change Point in Clinical Studies
Cox regression with an unknown change point and the corresponding large sample theory are discussed. We show how the results of this approach can be applied to computer-simulated data and to failure-time data from a large cohort of children treated at St. Jude Children’s Research Hospital for newly diagnosied acute lymphoblastic leukemia.
KeywordsAcute Lymphoblastic Leukemia Change Point FORTRAN Subroutine Dental Abnormality Hazard Rate Model
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