Energy Loss Spectrometry for Biological Research

  • Dale E. Johnson


Electron Energy Loss Spectrometry as a technique for the study of biological specimens is still very much in the early stages of development. Because of its high information gathering efficiency and high energy resolution (see Ch. 7, Joy) the potential for the use of ELS in the microanalytical study of biological thin specimens seems clear. However, it is also appreciated that certain problems (e.g. background intensity, radiation damage) are fundamental limitations to the full exploitation of this ELS potential. The current experimental situation is one in which both a variety of applications are being evaluated and, at the same time, the fundamental characteristics of the technique are being investigated, hopefully leading to optimum experimental parameters for application of the technique.


Energy Loss Electron Energy Loss Spectrometry High Energy Resolution Elemental Microanalysis Mass Thickness 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Brunger, W., and Menz, W., 1965, Zeit. Fur Phys., 184, 271.CrossRefGoogle Scholar
  2. Costa, J.L., Joy, D.C., Maher, D.M., Kirk, K., and Hui, S., 1978, Science, 200, 537.CrossRefGoogle Scholar
  3. Daniels, J., Festenberg, C.V., Raether, H., and Zeppenfeld, D., 1970, Springer Tracts in Modern Physics, (Berlin: Springer-Verlag), 54, 77.Google Scholar
  4. Haínfeld, J., and Isaacson, M., 1978, Ultramicroscopy, 3, 87.CrossRefGoogle Scholar
  5. Isaacson, M.S., Johnson, D.E., and Crewe, A.V., 1973, Rad. Res., 55, 205.CrossRefGoogle Scholar
  6. Isaacson, M.S., and Johnson, D.E., 1975, Ultramicroscopy, 1, 33.CrossRefGoogle Scholar
  7. Isaacson, M.S. and Utlaut, M., 1978, Optic, 50, 213.Google Scholar
  8. Jeancuillaume, C., Trebbia, D., and Colliex, C., 1978, Ultramicroscopy, 3, 237.CrossRefGoogle Scholar
  9. Johnson, D.E., 1972, Rad. Res., 49, 63.CrossRefGoogle Scholar
  10. Kincaid, M.M., Meixner, A.E., and Platzman, P.M., 1978, Phys. Rev. Let., 40, 1296.CrossRefGoogle Scholar
  11. Shuman, H., Somlyo, A.V., and Somlyo, A.P., 1976, Ultramicroscopy, 1, 317.CrossRefGoogle Scholar
  12. Stern, E.A., Contemp. Phys. 4, 289. (1978).CrossRefGoogle Scholar

Classic References

  1. See Ch. 7 (Joy) for a complete list.Google Scholar

Copyright information

© Springer Science+Business Media New York 1979

Authors and Affiliations

  • Dale E. Johnson
    • 1
  1. 1.Center for Bioengineering RF-52University of WashingtonSeattleUSA

Personalised recommendations