Advertisement

Does Albumin Infusion Affect Survival? Review of Meta-analytic Findings

  • M. M. Wilkes
  • R. J. Navickis

Abstract

Since its introduction more than 50 years ago, albumin has been in widespread use for the fluid management of acutely ill patients. In the US, the licensed indications for albumin include hypovolemia/shock, burns, hypoalbuminemia/hypoproteinemia, surgery, trauma, cardiopulmonary bypass (CPB), adult respiratory distress syndrome (ARDS), hemodialysis, acute nephrosis, hyperbilirubinemia, acute liver failure, ascites, and sequestration of protein rich fluids in acute peritonitis, pancreatitis, mediastinitis, and extensive cellulitis.

Keywords

Adult Respiratory Distress Syndrome Hydroxyethyl Starch Spontaneous Bacterial Peritonitis Colloid Osmotic Pressure Albumin Infusion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Tullis JL (1977) Albumin. 1. Background and use. JAMA 237: 355–360PubMedCrossRefGoogle Scholar
  2. 2.
    Cochrane Injuries Group Albumin Reviewers (1998) Human albumin administration in critically ill patients: systematic review of randomised controlled trials. Br Med J 317: 235–240CrossRefGoogle Scholar
  3. 3.
    Wilkes MM, Navickis RJ (2001) Patient survival after human albumin administration: a meta-analysis of randomized, controlled trials. Ann Intern Med 135: 149–164PubMedCrossRefGoogle Scholar
  4. 4.
    The Albumin Reviewers, Alderson P, Bunn F, et al (2000) Human albumin solution for resuscitation and volume expansion in critically ill patients. Cochrane Database Syst Rev CD 001208Google Scholar
  5. 5.
    Erstad BL (1999) Concerns with defining appropriate uses of albumin by meta-analysis. Am J Health Syst Pharm 56: 1451–1454PubMedGoogle Scholar
  6. 6.
    Webb AR (2000) The appropriate role of colloids in managing fluid imbalance: a critical review of recent meta-analytic findings. Crit Care 4 (suppl 2): S26–S32PubMedCrossRefGoogle Scholar
  7. 7.
    Sort P, Navasa M, Arroyo V, et al (1999) Effect of intravenous albumin on renal impairment and mortality in patients with cirrhosis and spontaneous bacterial peritonitis. N Engl J Med 341: 403–409PubMedCrossRefGoogle Scholar
  8. 8.
    von Hoegen I, Waller C (2001) Safety of human albumin based on spontaneously reported serious adverse events. Crit Care Med 29: 994–996CrossRefGoogle Scholar
  9. 9.
    Juni P, Witschi A, Bloch R, Egger M (1999) The hazards of scoring the quality of clinical trials for meta-analysis. JAMA 282: 1054–1060PubMedCrossRefGoogle Scholar
  10. 10.
    Moher D, Pham B, Jones A, et al (1998) Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses? Lancet 352: 609–613PubMedCrossRefGoogle Scholar
  11. 11.
    Rossouw JE, Lewis B, Rifkind BM (1990) The value of lowering cholesterol after myocardial infarction. N Engl J Med 323: 1112–1119PubMedCrossRefGoogle Scholar
  12. 12.
    Egger M, Dickersin K, Davey Smith G (2001) Problems and limitations in conducting systematic reviews. In: Egger M, Davey Smith G, Altman DG (eds) Systematic Reviews in Health Care: Meta-Analysis in Context, 2nd edn. BMJ Publishing Group, London, pp 43–68CrossRefGoogle Scholar
  13. 13.
    Wilkinson P, Sherlock S (1962) The effect of repeated albumin infusions in patients with cirrhosis. Lancet 2: 1125–1129PubMedCrossRefGoogle Scholar
  14. 14.
    Bland RD, Clarke TL, Harden LB, et al (1973) Early albumin infusion to infants at risk for respiratory distress. Arch Dis Child 48: 800–805PubMedCrossRefGoogle Scholar
  15. 15.
    Recinos PR, Hartford CA, Ziffren SE (1975) Fluid resuscitation of burn patients comparing a crystalloid with a colloid containing solution: a prospective study. J Iowa Med Soc 65: 426–432PubMedGoogle Scholar
  16. 16.
    Hallowell P, Bland JH, Dalton BC, et al (1978) The effect of hemodilution with albumin or Ringer’s lactate on water balance and blood use in open-heart surgery. Ann Thorac Surg 25: 22–29PubMedCrossRefGoogle Scholar
  17. 17.
    Virgilio RW, Metildi LA, Peters RM, Shackford SR (1979) Colloid vs crystalloid volume resuscitation of patients with severe pulmonary insufficiency. Surg Forum 30: 166–168PubMedGoogle Scholar
  18. 18.
    Metildi LA, Shackford SR, Virgilio RW, Peters RM (1984) Crystalloid versus colloid in fluid resuscitation of patients with severe pulmonary insufficiency. Surg Gynecol Obstet 158: 207–212PubMedGoogle Scholar
  19. 19.
    Rackow EC, Falk JL, Fein IA, et al (1983) Fluid resuscitation in circulatory shock: a comparison of the cardiorespiratory effects of albumin, hetastarch, and saline solutions in patients with hypovolemic and septic shock. Crit Care Med 11: 839–850PubMedCrossRefGoogle Scholar
  20. 20.
    Pockaj BA, Yang JC, Lotze MT, et al (1994) A prospective randomized trial evaluating colloid versus crystalloid resuscitation in the treatment of the vascular leak syndrome associated with interleukin-2 therapy. J Immunother 15: 22–28CrossRefGoogle Scholar
  21. 21.
    So KW, Fok TF, Ng PC, Wong WW, Cheung KL (1997) Randomised controlled trial of colloid or crystalloid in hypotensive preterm infants. Arch Dis Child Fetal Neonatal Ed 76: F43–46PubMedCrossRefGoogle Scholar
  22. 22.
    Bodenhamer RM, Johnson RG, Randolph JD, et al (1985) The effect of adding mannitol or albumin to a crystalloid cardioplegic solution: a prospective, randomized clinical study. Ann Thorac Surg 40: 374–379PubMedCrossRefGoogle Scholar
  23. 23.
    Grundmann R, Heistermann S (1985) Postoperative albumin infusion therapy based on colloid osmotic pressure. A prospectively randomized trial. Arch Surg 120: 911–915Google Scholar
  24. 24.
    Greenhalgh DG, Housinger TA, Kagan RJ, et al (1995) Maintenance of serum albumin levels in pediatric burn patients: a prospective, randomized trial. J Trauma 39: 67–73PubMedCrossRefGoogle Scholar
  25. 25.
    Grundmann R, von Lehndorff C (1986) Zur Indikation der postoperativen Humanalbumintherapie auf der Intensivstation-eine prospektiv randomisierte Studie. Langenbecks Arch Chir 367: 235–246PubMedCrossRefGoogle Scholar
  26. 26.
    Ginès P, Titó L, Arroyo V, et al (1988) Randomized comparative study of therapeutic paracentesis with and without intravenous albumin in cirrhosis. Gastroenterology 94: 1493–1502PubMedGoogle Scholar
  27. 27.
    Marelli D, Paul A, Samson R, Edgell D, Angood P, Chiu RC (1989) Does the addition of albumin to the prime solution in cardiopulmonary bypass affect clinical outcome? A prospective randomized study. J Thorac Cardiovasc Surg 98: 751–756PubMedGoogle Scholar
  28. 28.
    Adam R, Astarcioglu I, Castaing D, Bismuth H (1991) Ringer’s lactate vs serum albumin as a flush solution for UW preserved liver grafts: results of a prospective randomized study. Transplant Proc 23: 2374–2375PubMedGoogle Scholar
  29. 29.
    Goslinga H, Eijzenbach V, Heuvelmans JH, et al (1992) Custom-tailored hemodilution with albumin and crystalloids in acute ischemic stroke. Stroke 23: 181–188PubMedCrossRefGoogle Scholar
  30. 30.
    London MJ, Franks M, Verrier ED, Merrick SH, Levin J, Mangano DT (1992) The safety and efficacy of ten percent pentastarch as a cardiopulmonary bypass priming solution. A randomized clinical trial. J Thorac Cardiovasc Surg 104: 284–296Google Scholar
  31. 31.
    Gentilini P, Casini-Raggi V, Di Fiore G, et al (1999) Albumin improves the response to diuretics in patients with cirrhosis and ascites: results of a randomized, controlled trial. J Hepatol 30: 639–645PubMedCrossRefGoogle Scholar
  32. 32.
    Oca MJ, Nelson M, Donn SM (1999) Randomized trial of normal saline (NS) versus 5% albumin ( ALB) for the treatment of neonatal hypotension. Pediatr Res 45: 1265Google Scholar
  33. 33.
    Lennihan L, Mayer SA, Fink ME, et al (2000) Effect of hypervolemic therapy on cerebral blood flow after subarachnoid hemorrhage: a randomized controlled trial. Stroke 31: 383–391PubMedCrossRefGoogle Scholar
  34. 34.
    de Jonge E, Levi M (2001) Effects of different plasma substitutes on blood coagulation: a comparative review. Crit Care Med 29: 1261–1267.PubMedCrossRefGoogle Scholar
  35. 35.
    Addonizio VP, Macarak J, Nicolaou KC, Edmunds LH, Colman RW (1979) Effects of prostacyclin and albumin on platelet loss during in vitro simulation of extracorporeal circulation. Blood 53: 1033–1042PubMedGoogle Scholar
  36. 36.
    Boldt J, Zickmann B, Ballesteros BM, Stertmann F, Hempelmann G (1992) Influence of five different priming solutions on platelet function in patients undergoing cardiac surgery. Anesth Analg 74: 219–225PubMedCrossRefGoogle Scholar
  37. 37.
    Wilkes MM, Navickis RJ, Sibbald WJ (2001) Albumin versus hydroxyethyl starch in cardiopulmonary bypass surgery: a meta-analysis of postoperative bleeding. Ann Thorac Surg 72: 527–534PubMedCrossRefGoogle Scholar
  38. 38.
    Task Force of the American College of Critical Care Medicine, Society of Critical Care Medicine (1999) Practice parameters for hemodynamic support of sepsis in adult patients in sepsis. Crit Care Med 27: 639–660CrossRefGoogle Scholar
  39. 39.
    Emerson TE (1989) Unique features of albumin: a brief review. Crit Care Med 17: 690–694PubMedCrossRefGoogle Scholar
  40. 40.
    Zoellner H, Jing Yun H, Lovery M, et al (1999) Inhibition of microvascular endothelial apoptosis in tissue explants by serum albumin. Microvasc Res 57: 162–173PubMedCrossRefGoogle Scholar
  41. 41.
    Iglesias J, Abernethy VE, Wang Z, Lieberthal W, Koh JS, Levine JS (1999) Albumin is a major serum survival factor for renal tubular cells and macrophages through scavenging of ROS. Am J Physiol 277: F711–722PubMedGoogle Scholar
  42. 42.
    Kamada T, McMillan DE, Sternlieb JJ, Bjork VO, Otsuji S (1988) Albumin prevents erythrocyte crenation in patients undergoing extracorporeal circulation. Scand J Thorac Cardiovasc Surg 22: 155–158PubMedCrossRefGoogle Scholar
  43. 43.
    Gibbs J, Cull W, Henderson W, Daley J, Hur K, Khuri SF (1999) Preoperative serum albumin level as a predictor of operative mortality and morbidity: results from the National VA Surgical Risk Study. Arch Surg 134: 36–42PubMedCrossRefGoogle Scholar
  44. 44.
    Jelenko C, Williams JB, Wheeler ML, et al (1979) Studies in shock and resuscitation I: Use of a hypertonic, albumin-containing, fluid demand regimen ( HALFD) in resuscitation. Crit Care Med 7: 157–167PubMedCrossRefGoogle Scholar
  45. 45.
    Mathru M, Rao TL, Kartha RK, Shanmugham M, Jacobs HK (1980) Intravenous albumin administration for prevention of spinal hypotension during cesarean section. Anesth Analg 59: 655–658PubMedCrossRefGoogle Scholar
  46. 46.
    Brown RO, Bradley JE, Bekemeyer WB, Luther RW (1988) Effect of albumin supplementation during parenteral nutrition on hospital morbidity. Grit Care Med 16: 1177–1182CrossRefGoogle Scholar
  47. 47.
    Isik AZ, Gokmen O, Zeyneloglu HB, Kara S, Keles G, Gulekli B (1996) Intravenous albumin prevents moderate-severe ovarian hyperstimulation in in vitro fertilization patients: a prospective, randomized and controlled study. Eur J Obstet Gynecol Reprod Biol 70: 179–183PubMedCrossRefGoogle Scholar
  48. 48.
    Prien T, Backhaus N, Pelster F, Pircher W, Bünte H, Lawin P (1990) Effect of intraoperative fluid administration and colloid osmotic pressure on the formation of intestinal edema during gastrointestinal surgery. J Clin Anesth 2: 317–323PubMedCrossRefGoogle Scholar
  49. 49.
    Vincent JL (2000) Fluid management: the pharmacoeconomic dimension. Crit Care 4 (suppl 2): 533–35Google Scholar
  50. 50.
    Herwaldt LA, Swartzendruber SK, Edmond MB, et al (1998) The epidemiology of hemorrhage related to cardiothoracic operations. Infect Control Hosp Epidemiol 19: 9–16PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • M. M. Wilkes
  • R. J. Navickis

There are no affiliations available

Personalised recommendations