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Molecular Mechanisms of Complement Activation during Ischemia and Reperfusion

  • C. L. F. Ciurana
  • C. E. Hack

Abstract

Ischemia is a frequent clinical problem occurring, amongst others, in myocardial infarction, transplantation, vascular surgery, and thrombo-embolic disease. The obvious treatment of ischemia is reperfusion of the jeopardized organ or tissue. However, when ischemia is too severe, reperfusion may exacerbate rather than limit tissue damage, a phenomenon known as ischemia/reperfusion (I/R)-injury. A number of studies have been performed to unravel the pathophysiology of I/R-injury, and it is now clear that this condition is mainly due to an inflammatory process elicited by reperfusion. Hence, limiting I/R-induced inflammatory reactions is expected to improve the efficacy of reperfusion. Indeed, inhibition of inflammatory mediators improves the beneficial effects of reperfusion of ischemic tissues in animal models. In this chapter we will summarize the role of inflammation in the pathogenesis of I/R-injury, and discuss in more detail that of the complement system, as this plasma cascade system seems to be a key mediator in this condition.

Keywords

Complement Activation Complement Inhibitor Complement Receptor Type Classical Complement Pathway Mannan Binding Lectin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • C. L. F. Ciurana
  • C. E. Hack

There are no affiliations available

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