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Bacterial CpG DNA in Septic Shock

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Intensive Care Medicine

Abstract

Septic shock develops when specific microbial components gain access to the circulation and are recognized by the immune system, generating exaggerated mediator and cytokine production. The main microbial components responsible for this recognition are lipopolysaccharide (LPS) in Gram-negative bacteria, or peptidoglycan and teichoic acid in Gram-positive bacteria. Microbial compounds display molecular pattern recognition receptors (PRR) — such as LPS receptors (Toll-like receptor [TLR]4 and CD14) which are expressed constitutively on innate immune system cells (macrophages and dendritics cells) [1].

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Authors
  1. E. Wiel
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  2. G. Lebuffe
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  3. B. Vallet
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Editor information

Editors and Affiliations

  1. Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennik 808, B-1070, Brussels, Belgium

    Jean-Louis Vincent MD, PhD, FCCM, FCCP (Head) (Head)

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Wiel, E., Lebuffe, G., Vallet, B. (2002). Bacterial CpG DNA in Septic Shock. In: Vincent, JL. (eds) Intensive Care Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-5551-0_35

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  • DOI: https://doi.org/10.1007/978-1-4757-5551-0_35

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4757-5553-4

  • Online ISBN: 978-1-4757-5551-0

  • eBook Packages: Springer Book Archive

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