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Intensive Care Medicine pp 287–293Cite as

Bronchodilator Therapy in Mechanically Ventilated Patients

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Abstract

Inhaled bronchodilators are a primary component of the treatment of airway obstruction [1, 2]. During acute respiratory failure due to airway obstruction (asthma attacks and exacerbations of chronic obstructive pulmonary disease [COPD]) their dosage and frequency of administration are increased up to the maximum [3, 4].

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References

  1. American Thoracic Society (1995) ATS standards for the diagnosis and care of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 152: S78 - S121

    Article  Google Scholar 

  2. British Thoracic Society (1997) The BTS guidelines for the management of chronic obstructive pulmonary disease. Thorax 52 (suppl 5): S1 - S28

    Google Scholar 

  3. Raimondi AC, Schottlender J, Lombardi D, Molfino NA (1997) Treatment of acute severe asthma with inhaled albuterol delivered via jet nebulizer, metered dose inhaler with spacer, or dry powder. Chest 112: 24–28

    Article  PubMed  CAS  Google Scholar 

  4. Rodrigo G, Rodrigo C (1996) Metered dose inhaler salbutamol treatment of asthma in the Emergency Department: comparison of two doses with plasma levels. Am J Emerg Med 14: 144–155

    Article  PubMed  CAS  Google Scholar 

  5. Bauer TT, Torres A (2001) Aerosolized ß2-agonists in the intensive care unit: just do it. Intensive Care Med 27: 3–5

    PubMed  CAS  Google Scholar 

  6. Jones A, Rowe B, Peters J, Camargo C, Hammarquist C (2000) Inhaled beta-agonists for asthma in mechanically ventilated patients. Cochrane Database Syst Rev 2:CD001493

    Google Scholar 

  7. Nava S, Navalesi P (1999) Bronchodilators and mechanical ventilation in COPD patients. Emptying, pumping or both? Intensive Care Med 25: 1206–1208

    Article  PubMed  CAS  Google Scholar 

  8. Macklem PT (1984) Hyperinflation Am Rev Respir Dis 129: 1–2

    CAS  Google Scholar 

  9. Similowski T, Yan S, Gauthier AP, Macklem PT, Bellemare F (1991) Contractile properties of the human diaphragm during chronic hyperinflation. N Engl J Med 325: 917–923

    Article  PubMed  CAS  Google Scholar 

  10. Bernasconi M, Brandolese R, Poggi R, Manzini E, Rossi A (1990) Dose-response effects and time course of effects of inhaled fenoterol on respiratory mechanics and arterial oxygen tension in mechanically ventilated patients with chronic obstructive pulmonary disease. Intensive Care Med 16: 108–114

    Article  PubMed  CAS  Google Scholar 

  11. Fernandez A, Lazaro A, Garcia A, Aragon C, Cerda E (1990) Bronchodilators in patients with chronic obstructive pulmonary disease on mechanical ventilation: utilisation of metered-dose inhalers. Am Rev Respir Dis 141: 164–168

    Article  PubMed  CAS  Google Scholar 

  12. Mancebo J, Amaro P, Lorino H, Lemaire F, Harf A, Brochard L (1991) Effects of albuterol inhalation on the work of breathing during weaning from mechanical ventilation. Am Rev Respir Dis 144: 95–100

    Article  PubMed  CAS  Google Scholar 

  13. Manthous CA, Chatila W, Schmidt GA, Hall JB (1995) Treatment of bronchospasm by metered-dose inhaler albuterol in mechanically ventilated patients. Chest 107: 210–213

    Article  PubMed  CAS  Google Scholar 

  14. Dhand R, Duarte AG, Jubran A, et al (1996) Dose-response to bronchodilator delivery by metered-dose inhaler in ventilator-supported patients. Am J Respir Crit Care Med 154: 388–393

    Article  PubMed  CAS  Google Scholar 

  15. Guerin C, Chevre A, Dessinier P, et al (1999) Inhaled fenoterol-ipratropium bromide in mechanically ventilated patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 159: 1036–1042

    Article  PubMed  CAS  Google Scholar 

  16. Mouloudi E, Katsanoulas K, Anastasaki M, Hoing S, Georgopoulos D (1999) Bronchodilator delivery by metered dose inhaler in mechanically ventilated COPD patients: influence of tidal volume. Intensive Care Med 25: 1215–1221

    Article  PubMed  CAS  Google Scholar 

  17. Mouloudi E, Prinianakis G, Kondili E, Georgopoulos D (2001) Effect of inspiratory flow rate on beta2-agonist induced bronchodilation in mechanically ventilated COPD patients. Intensive Care Med 27: 42–46

    Article  PubMed  CAS  Google Scholar 

  18. Appendini L, Purro A, Patessio A, et al (1996) Partitioning of inspiratory muscle workload and pressure assistance in ventilator-dependent COPD. Am J Respir Crit Care Med 154: 1301–1309

    Article  PubMed  CAS  Google Scholar 

  19. Vassilakopoulos T, Zakynthinos S, Roussos C (1998) The tension-time index and the frequency/tidal volume ratio are the major pathophysiologic determinants of weaning failure and success. Am J Respir Grit Care Med 158: 378–385

    Article  CAS  Google Scholar 

  20. Maesen BLP, Westermann CJJ, Duurkens VAM, Van den Bosch JMM (1999) Effects of formeterol in apparently poory reversible chronic obstructive pulmonary disease. Eur Respir J 13: 1103–1108

    Article  PubMed  CAS  Google Scholar 

  21. Nava S, Compagnoni ML (2000) Controlled short-term trial of fluticasone propionate in ventilator-dependent patients with COPD. Chest 118: 990–999

    Article  PubMed  CAS  Google Scholar 

  22. Salmeron S, Brochard L, Mal H, et al (1994) Nebulized versus intravenous albuterol in hypercapnic acute asthma. A multicenter, double-blind, randomized study. Am J Respir Crit Care Med 149: 1466–1470

    Article  PubMed  CAS  Google Scholar 

  23. Fuller HD, Dolovich MB, Posmituck G, Wong Pack W, Newhouse MT (1990) Pressurized aerosol versus jet aerosol delivery to mechanically ventilated patients. Am Rev Respir Dis 141: 440–444

    Article  PubMed  CAS  Google Scholar 

  24. Manthous CA, Hall JB, Schmidt GA, Wood LDH (1993) Metered dose inhaler versus nebulized albuterol in mechanically ventilated patients. Am Rev Respir Dis 148: 1567–1570

    Article  PubMed  CAS  Google Scholar 

  25. Dhand R, Tobin M (1997) Inhaled bronchodilator therapy in mechanically ventilated patients. Am J Respir Crit Care Med 156: 3–10

    Article  PubMed  CAS  Google Scholar 

  26. Fink JB, Dhand R, Grychowski J, Fahey PJ, Tobin MJ (1999) Reconciling in vitro and in vivo measurements of aerosol delivery from a metered-dose inhaler during mechanical ventilation and defining efficiency-enhancing factors. Am J Respir Crit Care Med 159: 63–68

    Article  PubMed  CAS  Google Scholar 

  27. Lange CF, Finlay WH (2000) Overcoming the adverse effect of humidity in aerosol delivery via pressurized metered-dose inhalers during mechanical ventilation. Am J Respir Grit Care Med 161: 1614–1618

    Article  CAS  Google Scholar 

  28. The Lung Health Study Research Group (2000) Effect of inhaled triamcinolone on the decline in pulmonary function in chronic obstructive pulmonary disease. N Engl J Med 343: 1902–1909

    Article  Google Scholar 

  29. Niewoehner DE, Erbland ML, Deupree RH, et al (1999) Effect of systemic glucocorticoids on exacerbations of chronic obstructive pulmonary disease. N Engl J Med 340: 1941–1947

    Article  PubMed  CAS  Google Scholar 

  30. Fink JB, Dhand R, Duarte AG, Jenne JW, Tobin MJ (1996) Aerosol delivery from a metered-dose inhaler during mechanical ventilation. An in vitro model. Am J Respir Crit Care Med 154: 382–387

    Google Scholar 

  31. Mouloudi E, Katsanoulas K, Anastasaki M, Askitopoulou E, Georgopoulos D (1998) Bronchodilator delivery by metered-dose inhaler in mechanically ventilated COPD patients: influence of end-inspiratory pause. Eur Respir J 12: 165–169

    Article  PubMed  CAS  Google Scholar 

  32. Mouloudi E, Prinianakis G, Kondili E, Georgopoulos D (2000) Bronchodilator delivery by metered-dose inhaler in mechanically ventilated COPD patients: influence of flow pattern. Eur Respir J 16: 263–268

    Article  PubMed  CAS  Google Scholar 

  33. Brochard L, Mancebo J, Wysocki M (1995) Noninvasive ventilation for acute exacerbations of chronic obstructive pulmonary disease. N Engl J Med 333: 817–822

    Article  PubMed  CAS  Google Scholar 

  34. Parkers SN, Bersten AD (1997) Aerosol kinetics and bronchodilator efficacy during continuous positive airway pressure delivered by face mask. Thorax 52: 171–175

    Article  Google Scholar 

  35. Nava S, Karakurt S, Rampulla C, Braschi A, Fanfulla F (2001) Salbutamol delivery during non invasive mechanical ventilation in patients with chronic obstructive pulmonary disease: a randomized controlled study. Intensive Care Med 27: 1627–1635

    Article  PubMed  CAS  Google Scholar 

  36. Jolliet P, Tassaux D, Thouret JM, Chevrolet JC (1999) Beneficial effects of helium:oxygen versus air: oxygen noninvasive pressure support in patients with decompensated chronic obstructive pulmonary disease. Crit Care Med 27: 2422–2429

    Article  PubMed  CAS  Google Scholar 

  37. Jaber S, Redouane F, Carlucci A (2000) Noninvasive ventilation with helium-oxygen in acute exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 161: 1191–1200

    Article  PubMed  CAS  Google Scholar 

  38. Goode ML, Fink JB, Dhand R, Tobin MJ (2001) Improvement in aerosol delivery with heliumoxygen mixtures during mechanical ventilation. Am J Respir Crit Care Med 163: 109–114

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. P. Navelesi
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  2. P. Ceriana
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  3. M. Delmastro
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Editor information

Editors and Affiliations

  1. Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennik 808, B-1070, Brussels, Belgium

    Jean-Louis Vincent MD, PhD, FCCM, FCCP (Head) (Head)

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© 2002 Springer Science+Business Media New York

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Navelesi, P., Ceriana, P., Delmastro, M. (2002). Bronchodilator Therapy in Mechanically Ventilated Patients. In: Vincent, JL. (eds) Intensive Care Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-5551-0_26

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  • DOI: https://doi.org/10.1007/978-1-4757-5551-0_26

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4757-5553-4

  • Online ISBN: 978-1-4757-5551-0

  • eBook Packages: Springer Book Archive

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