Neural Control of Mechanical Ventilation: A New Approach to Improve Patient-Ventilator Interaction

  • J. Spahija
  • J. Beck
  • C. Sinderby


Mechanical ventilation is used to treat acute respiratory failure. In its most conservative form, mechanical ventilation completely replaces the breathing function of the patient. These so-called ‘controlled’ modes of mechanical ventilation usually require that the patient be sedated or even paralyzed. In non-sedated and spontaneously breathing patients, mechanical ventilation can be delivered by modes of partial ventilatory assist, where mechanical ventilation assists breathing in such a way that ventilation is maintained and that respiratory muscle failure is avoided by unloading the respiratory muscles. Preferably, the ventilatory assist should be delivered in response to the output from respiratory centers, i.e., respond to changes in respiratory demand. Since the respiratory center output is not constant within a given breath, and its duration, shape, and amplitude vary from one breath to the next, a challenge for the application of partial ventilatory assist is therefore to accurately determine:
  • when to cycle-on and cycle-off the assist during each breath (triggering)

  • the profile of assist delivered within a breath (intra-breath assist profile)

  • the level of assist during each breath (level of assist)


Mechanical Ventilation Respir Crit Inspiratory Muscle Intrinsic Peep Crural Diaphragm 


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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • J. Spahija
  • J. Beck
  • C. Sinderby

There are no affiliations available

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