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Critical Care of Myasthenic Crisis

  • N. Janjua
  • S. A. Mayer
Conference paper

Abstract

Myasthenia gravis is an autoimmune disorder caused by antibodies directed against the postsynaptic acetylcholine receptor (AchR) of skeletal muscle [1,2]. The disease carries a 2:1 female to male predominance and follows a bimodal age distribution, peaking before age 50 among women and again in late midlife among men [3, 4]. Older cases of newly diagnosed myasthenia are more commonly associated with thymoma. Myasthenic crisis, defined as respiratory failure requiring mechanical ventilation, is a potentially life-threatening complication that occurs in approximately 15 to 20% of patients [2, 5]. An even greater percentage of all patients affected with the disease experience some degree of respiratory muscle weakness [2, 5, 6].

Keywords

Vital Capacity Noninvasive Positive Pressure Ventilation Respiratory Muscle Weakness Pyridostigmine Bromide Myasthenic Crisis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • N. Janjua
  • S. A. Mayer

There are no affiliations available

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