Endothelial Cell Replacement Therapy in the Critically Ill
One of the long-standing goals of medical research is to find methods of regenerating damaged and destroyed tissues and vital organs. Solid organ transplantation is well established in the treatment of irreversible single organ failure. However, it is severely limited by lack of suitable organs, the problems of tissue rejection, and the need for significant and long-term immunosuppressive treatment. Although the occasional patient with critical illness will benefit from single organ transplantation, it remains extremely unlikely that solid organ transplantation for multi-organ failure (MOF) will ever become a realistic clinical prospect.
KeywordsVascular Endothelial Growth Factor Endothelial Progenitor Cell Vascular Repair Endothelial Cell Loss Hindlimb Ischemia
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