Endogenous Anticoagulants and the Role of Heparin in the Treatment of Severe Sepsis

  • C. J. Wiedermann
  • C. Pechlaner
Conference paper


New treatments for severe sepsis have yielded disappointing results in numerous trials conducted in the past 20 years. The interventions tested improved survival only marginally, if at all. Some were associated with unexpected toxicities. Not a single new agent had been introduced into clinical practice until recently [1–4].


Severe Sepsis Disseminate Intravascular Coagulation Disseminate Intravascular Coagulation Tissue Factor Pathway Inhibitor Drotrecogin Alfa 


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© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • C. J. Wiedermann
  • C. Pechlaner

There are no affiliations available

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