Genetic Basis of Host Resistance and Susceptibility to Intracellular Pathogens

  • Emil Skamene
  • Adrien Forget
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 239)


History provides numerous examples of variable susceptibility of human populations to viral, bacterial and parasitic infections, both during epidemics and in the endemic areas of the world. Although the influence of environmental factors must be considered in any explanation of such variability, it has recently become clear, mainly on the basis of studying experimental infections in inbred animals, that genetic factors play decisive role in individual susceptibility.


Visceral Leishmaniasis Host Resistance Intracellular Pathogen Recombinant Inbred Inbred Mouse Strain 


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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Emil Skamene
    • 1
  • Adrien Forget
    • 2
  1. 1.Division of Clinical Immunology and AllergyMontreal General HospitalMontrealCanada
  2. 2.Department of Microbiology and ImmunologyUniversity of MontrealMontrealCanada

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