Effect of Tumor Necrosis Factor on Growth of Trypanosoma Musculi in Vivo and in Vitro
Trypanosome musculi, a natural parasite of mice, produces a self-limiting infection which lasts for approximately 3 weeks and comprises an early growth phase, a plateau phase and an elimination phase (1). The mechanism of protection which controls the early growth of the parasite, leading to the plateau phase, is not well understood but is known to be highly sensitive to ionizing radiation. Macrophages of the reticuloendothelial system also become activated at this time (2). We have shown recently that elimination of parasitaemia and termination of the infection depends on an effector mechanism involving a thermolabile, anti-trypanosomal IgG2a antibody, complement component C3 and an effector cell, possibly a macrophage (3,4).
KeywordsPlateau Phase Trypanosoma Cruzi Malarial Parasite Peritoneal Exudate Cell Natural Parasite
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