Role of Natural Killer Cells in the Early Clearance of Rickettsia Typhi in Mice
Clearance of the intracellular bacterium, Rickettsia typhi has been a field of much recent inquiry. Cells which transfer immunity arise late during the course of infection, bear the Thy-1 antigen (1) and are H-2 restricted. Further, H-2 restricted cytotoxic T-cells functional in vitro also arise at approximately the same time (2), and are believed to belong to the same lineage as those which transfer immunity (3). Examination of the kinetics of the immune response, however, reveals that the onset of the cellular response, as well as that of IgG antibodies, occurs as much as one week after the organisms have been cleared. How, then, is the early clearance of infection brought about?
KeywordsNatural Killer Natural Killer Cell Visceral Leishmaniasis Natural Cytotoxic Rickettsial Infection
Unable to display preview. Download preview PDF.
- 3.Dasch, G., and F.M. Rollwagen. Characterization of cells which transfer immunity to rickettsial infection. Manuscript in preparation.Google Scholar
- 4.Turco, J., and Winkler, H.H. 1983. Inhibition of the growth of Rickettsia prowazekii in cultured fibroblasts by lymphokines. J. Exp. Med. 157: 974.Google Scholar
- 5.Djeu, J.Y., J.A. Heinbaugh, H.T. Holden, and R.B. Herberman. 1979. Augmentation of mouse natural killer cell activity by interferon and interferon inducers. J. Inmunol. 122: 175.Google Scholar
- 6.Stutman, O., E. Feo Figarella, C.J. Paige, and E.C. Lattime. 1980. Natural cytotoxic (NC) cells against solid tumors in mice: general characteristics and comparison to natural killer (NK) cells. In: Natural Cell-Mediated Immunity against Tumors. Ed. by R.B. Herberman, Academic Press, N.Y., p. 187.Google Scholar
- 7.Palmer, B.A., F.M. Hetrick, and T.R. Jerrells. 1984. Gamma interferon production in response to homologous and heterologous strain antigens in mice chronically infected with Rickettsia tsutsugamushi. Infect. Immun. 46: 237.Google Scholar
- 11.Weiss, E., J.C. Coolbaugh, and J.C. Williams. 1975. Separation of viable Rickettsia typhi from yolk sac and L cell host components by Renografin density gradient centrifugation. Appl. Microbiol. 30: 456.Google Scholar
- 12.Bean, M.A., Y. Kodera, and H. Shiku. 1976. Tritiated-proline microcytotoxicity assay for the study of cellular and humoral immune reaction directed against target cells grown in monolayer cultures. In: In vitro Methods in Cell Mediated and Tumor Immunity. B.R. Bloom and J.R. David, eds. Academic Press, New York, p. 471.Google Scholar
- 13.Jerrells, T.R. 1986. Mechanisms of immunity to Rickettsia species and Coxiella burnetii. In: Biology of Rickettsial Diseases. Walker, D.H., Ed. CRC-Press, Boca Raton, FL, in press.Google Scholar
- 17.Skamene, E., M.M. Stevenson, and S. Lemieux. 1983. Murine malaria: dissociation of natural killer (NK) cell activity and resistance to Plasmodium chabaudi. Parasite Immunol. 5: 557.Google Scholar
- 18.Kirkpatrick, C.E., J.P. Farrell, J.F. Warner, and G. Dennert. 1985. Participation of natural killer cells in the recovery of mice from visceral leishmaniasis. Cell. Inmunol. 92: 163.Google Scholar
- 20.Li, H., T.R. Jerrells, and D.H. Walker. 1986. Evidence for the role of gamma-interferon as a crucial host defense against Rickettsia conorii in vivo. Am. Soc. for Rickettsiology, Williamsburg, Va.Google Scholar
- 21.Handa, K., R. Suzuki, H. Matsui, Y. Shimizu, and K. Kumagai. 1983. Natural killer (NK) cells as a responder to interleukin-2 (IL-2). II. IL 2-induced interferon-y production. J. Inmunol. 130: 988.Google Scholar