Fiberoptics in Confocal Microscopy

  • P. M. Delaney
  • M. R. Harris


During the past 30 or so years, fiberoptics research has seen enormous developments, driven mostly by the benefits to be gained in telecommunications. However, the resultant standards of performance and production of optical fibers have permitted numerous adaptations in analytical instrumentation. For example, optical fibers can be used in remote sensing applications (by taking analysis to the sample, rather than bringing the sample to the analytical instrument) and/or to increase the modularity of instrumentation by providing flexible connectivity between isolated optical devices that would otherwise require complete hardware integration.


Optical Fiber Fiber Output Multimode Fiber Entrance Pupil Detection Aperture 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Born, M., and Wolf, E., 1980, Principles of Optics, 6th ed., Pergamon Press, Oxford, Sect. 1.5.2.Google Scholar
  2. Delaney, P.M., Harris, M.H., and King, R.G., 1993a, Novel microscopy using fiber optic confocal imaging and its suitability for subsurface blood vessel imaging in vivo, Clin. Exp. Pharmacol. Physiol. 20:197–198.CrossRefGoogle Scholar
  3. Delaney, P.M., Harris, M.H., and King, R.G., 1993b, Remote interrogation of objective lenses using a novel fiber optic confocal microscope reduces movement artefacts. In: 1993 International Conference on Confocal Microscopy and 3D Image Processing Proceedings, Sydney, Australia, Feb. 1993, p. 66.Google Scholar
  4. Delaney, P.M., Harris, M.H., and King, R.G., 1994a, Fiber-optic laser scanning confocal microscope suitable for fluorescence imaging, Appl. Optics. 33:573–577.CrossRefGoogle Scholar
  5. Delaney, P.M., King, R.G., Lambert, J.R., and Harris, M.H., 1994b, Fiber optic confocal imaging (FOCI) for subsurface imaging of the colon in vivo, J. Anat. 184:157–160.Google Scholar
  6. Gimitri, A.F., and Aziz, D., 1993, Confocal microsocpy through a fiber-optic imaging bundle, Opt. Lett. 18:565–567.CrossRefGoogle Scholar
  7. Giniunas, L., Juskaitis, R., and Shatalin, V., 1991, Scanning fiber-optic microscope, Electron. Lett. 27:724–726.CrossRefGoogle Scholar
  8. Gu, M., and Sheppard, C.J.R., 1991, Signal level of the fiber-optical confocal scanning microscope, J. Opt. Soc. Am. A8:1755–1761.CrossRefGoogle Scholar
  9. Katzir, A., 1993, Lasers and Optical Fibers in Medicine, Academic Press, San Diego.Google Scholar
  10. Kimura, S., and Wilson, T., 1991, Confocal scanning optical microscope using single mode fiber for signal detection, Appl. Optics 30:2143–2150.CrossRefGoogle Scholar
  11. Sharonov, S., Morjani, H., and Manfait, M., 1992, Confocal spectral imaging analysis: A new concept to study the drug distribution in a single living cancer cell, Anticancer Res. 12:1804.Google Scholar
  12. Snyder, A.W., and Love, J.D., 1983, Optical Waveguide Theory, Chapman and Hall, London.Google Scholar
  13. Wilson, J., and Hawkes, J.F.B., 1989a, Optoelectronics. An Introduction, 2nd ed., Prentice-Hall, Hemel, Hempstead, Sects. 8.3.3, 8.3.4, and 8.5.2.Google Scholar
  14. Wilson, J., and Hawkes, J.F.B., 1989b, Optoelectronics. An Introduction, 2nd ed., Prentice-Hall, Hemel, Hempstead, Sect. 8.5.2.Google Scholar
  15. Wilson, T., Juskaitis, R., and Rimvidas, 1992, Confocal and differential microscopy using optical fiber detection. In: Proceedings of SPIE-International Society for Optical Engineering, vol. 1660 pt. 2.Google Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • P. M. Delaney
    • 1
  • M. R. Harris
    • 2
  1. 1.Department of PharmacologyMonash UniversityClaytonAustralia
  2. 2.H.B.H. Technological Industries Pty., Ltd.DardenongAustralia

Personalised recommendations