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Topographical Distribution of the Gangliosides in the Developing and Adult Human Brain

  • Ivica Kracun
  • Harald Rösner
  • Cedomir Cosovic
Part of the FIDIA Research Series book series (FIDIA, volume 6)

Abstract

In contrast to the experimental knowledge about gangliosides, there are relatively few studies describing gangliosides in the developing (Vanier et al., 1971; Yusuf et al., 1977; Martinez and Ballabriga, 1978; Kracun et al., 1983) and adult (Suzuki, 1965; Riboni et al., 1985) human brain. The developmental studies revealed that the prenatal period of “growth spurt”, occurring between 15 and 30 weeks of gestation (Sidman and Rakic, 1973), is paralleled by an increase in the content of gangliosides and a change in their composition. In animal studies similar developmental changes of gangliosides have been confirmed as consecutive phenomena of neuron genesis, neuronal differentiation, synaptogenesis and myelination (Dreyfus et al., 1980; Rösner, 1977; 1980; 1982).

Keywords

Sialic Acid Adult Human Brain Brain Ganglioside Total Ganglioside Ganglioside Content 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

A

amygdalea

As

area subcallosa

Cc

cerebellar cortex

CC

corpus callosum

CI

capsula interna

CIn

colliculi inferiores

CM

corpora mammillaria

CS

colliculi superiores

E

epiphysis (pineal gland)

F

frontal cortex

FW

frontal white matter

gC

gyrus cinguli

Gd

gyrus dentatus

GP

globus pallidus

h

hippocampus

Hy

hypothalamus

I

insular cortex

LC

locus coeruleus

Nac

nucleus accumbens

NBM

nucleus basalis Meynert

NC

nucleus caudatus

NeuAc

N-acetylneuraminic acid

Nr

nucleus ruber

Oc

occipital cortex

Of

orbitofrontal cortex

oh

optic chiasma

P

putamen

Pf

prefrontal cortex

Pr

parietal cortex

Sn

substantia nigra

Sr

striatal (visual) cortex

T

temporal cortex

TLC

thin-layer chromatography

Th

thalamus

Thp

pulvinar thalami

To

paleocortex (tuberculum olfactorium).

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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • Ivica Kracun
    • 1
    • 2
  • Harald Rösner
    • 3
  • Cedomir Cosovic
    • 1
  1. 1.Department of Chemistry and BiochemistryMedical FacultyZagrebYugoslavia
  2. 2.Rebro, Neurobiochemical LaboratoryClinical Hospital CenterYugoslavia
  3. 3.Institute of ZoologyUniversity HohenheimStuttgartFederal Republic of Germany

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