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Gangliosides and Neuronal Plasticity pp 465–479Cite as

Ganglioside Therapy of Peripheral Neuropathies: A Review of Clinical Literature

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Part of the book series: FIDIA Research Series ((FIDIA,volume 6))

Abstract

The present report aims at presenting a synthetic review of the most important clinical trials which use gangliosides as therapeutic agents in peripheral neuropathies of various etiology. The complex of biochemical and pharmacological research studies on gangliosides indicates that these molecules, natural components of cellular membranes (in particular, of neuronal membranes) are involved in neuronal development, differentiation and regeneration processes. The ganglioside preparation has been shown to possess a reinnervation-stimulating activity due to enhanced nerve sprouting, an essential feature of muscular reinnervation processes and of restoration of synaptic contacts. Electrophysiological and functional evidence of early recovery from nerve damage, due to parenteral ganglioside treatment, has been obtained in several animal models, including motor nerve function after nerve crush, sensory nerve function after transection, cochler impairment by noise, diabetic neuropathy in mutant diabetic mice and toxic damage to peripheral nerves (Ceccarelli et al., 1976; Gorio et al., 1980; 1983; 1984; Leon et al., 1981).

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Author information

Authors and Affiliations

  1. Clinical Research Dept., Fidia Research Laboratories, Abano Terme, Italy

    Marino Massarotti

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  1. Marino Massarotti
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Editors and Affiliations

  1. Dipartimento di Chimica e Biochimica Medica, Facoltà di Medicina e Chirurgia, Università di Milano, Milano, Italy

    Guido Tettamanti

  2. Dept of Neurology and Biochemistry, Albert Einstein College of Medicine, Bronx, New York, USA

    Robert W. Ledeen

  3. Institut für Organische, Chemie und Biochemie, Universität Bonn, Bonn, Germany

    Konrad Sandhoff

  4. Dept of Biochemistry, University of Tokyo, Tokyo, Japan

    Yoshitaka Nagai

  5. Dept of Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan

    Yoshitaka Nagai

  6. Research Laboratories, Fidia Neurobiological, Abano Terme, Italy

    Gino Toffano

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© 1986 Springer-Verlag Berlin Heidelberg

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Massarotti, M. (1986). Ganglioside Therapy of Peripheral Neuropathies: A Review of Clinical Literature. In: Tettamanti, G., Ledeen, R.W., Sandhoff, K., Nagai, Y., Toffano, G. (eds) Gangliosides and Neuronal Plasticity. FIDIA Research Series, vol 6. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-5309-7_39

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  • DOI: https://doi.org/10.1007/978-1-4757-5309-7_39

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4757-5311-0

  • Online ISBN: 978-1-4757-5309-7

  • eBook Packages: Springer Book Archive

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