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Subacute Phase of Stroke Treated with Ganglioside GM1

  • S. Bassi
  • M. G. Albizzati
  • M. Sbacchi
  • L. Frattola
  • M. Massarotti
Part of the FIDIA Research Series book series (FIDIA, volume 6)

Abstract

Various effects of treatment with GM1 ganglioside were shown:
  1. a)

    enhancement of neuronal sprouting and neuritogenesis (potentiating the effects of trophic factors) (Cotman et al., 1981; Gorio et al., 1980; Wojcik et al., 1982; Toffano et al., 1983; Ferrari et al., 1983);

     
  2. b)

    functional recovery of dopaminergic and cholinergic activity after lesion (Toffano et al., 1983);

     
  3. c)

    reduction of cerebral edema (Karpiak, 1983);

     
  4. d)

    prevention of progressive neural damage following trauma by means of complex intracellular mechanisms (activation of membrane bound enzymes) (Seifert, 1981).

     

Keywords

Central Nervous System Disease Neuronal Plasticity Septal Lesion Nervous System Disease Subacute Phase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

CT-scan

Computerized assial Tomography

EEG

electroencephalography

i.m.

intramuscular injection.

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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • S. Bassi
    • 1
  • M. G. Albizzati
    • 1
  • M. Sbacchi
    • 1
  • L. Frattola
    • 2
  • M. Massarotti
    • 3
  1. 1.Neurological ClinicBassini HospitalMilanoItaly
  2. 2.Neurological ClinicUniversity of Milan, S. Gerardo dei Tintori HospitalMonzaItaly
  3. 3.Fidia Research LaboratoriesAbano Terme (Padova)Italy

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