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Effect of GMI Ganglioside and of Its Inner Ester Derivative in a Model of Transient Cerebral Ischemia in the Rat

  • Jean Cahn
  • Marie-Gilberte Borzeix
  • Gino Toffano
Part of the FIDIA Research Series book series (FIDIA, volume 6)

Abstract

Among the agents affecting neurite growth responses a particular role has been attributed to gangliosides. These are glycosphingolipids, sialic-acid containing membrane components (Ledeen, 1978) which are involved in development, differentiation and regeneration (Rapport and Gorio, 1981). GMI ganglioside intraperitoneally injected into rats after unilateral hemitransection produces a marked stimulation of collateral sprouting of dopaminergic axons in the striatum and maintains the number of dopaminergic cell bodies in the substantia nigra ipsilateral to the lesion (Toffano et al., 1983; 1984; Agnati et al., 1983).

Keywords

Cerebral Blood Flow Tyrosine Hydroxylase Ester Derivative Transient Cerebral Ischemia Dopaminergic Axon 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

KCA

middle cerebral artery

ECP

energy charge potential

CBF

cerebral blood flow

MABP

mean arterial blood pressure

ISI

initial slope index

ECoG

electrocorticographic

c.p.

intraperitoneal injection, TH, tyrosine hydroxylase

DMP4

6,7-dimethyl-5,6,7,8-tetrahydro pterine hydrochloride.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • Jean Cahn
    • 1
  • Marie-Gilberte Borzeix
    • 1
  • Gino Toffano
    • 2
  1. 1.Department of Experimental TherapySIR internationalMontrougeFrance
  2. 2.Neurobiological Research LaboratoriesFIDIA Research LaboratoriesAbano Terme, PadovaItaly

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