Effect of GM1 on the Alterations Induced by Selective Neurotoxins in the Developing CNS
The effect of the monosialoganglioside GM1 administration on the alterations induced in rat CNS by neurotoxins selective for transmitter-identified neurons has been studied by employing both neuro- and immunocytochemical techniques. 5,7-dihydroxytryptamine (5,7-HT), 6-hydroxydopamine (6-OH-DA) and capsaicin have been used to induce damage to serotonin (5-HT)-, noradrenaline (NA)- and substance P (SP)- containing neurons, respectively. In experiments employing 5,7-HT and 6-OH-DA it is found that the primary neurodegenerative actions of these neurotoxins on NA and 5-HT neurons are not modified by GM1 administration. In contrast under chronic conditions, GM1 diminishes the extent of the alterations induced by 5,7-HT and 6-OH-DA. Moreover, GM1 is able to reduce the capsaicin-induced decrease of SP nerve terminal density in the superficial layers of the dorsal horns of lumbar spinal sections. The present results are consistent with the view that GM1 has a protective and/or regrowth-stimulating effect on damaged central neurons.
KeywordsNerve Growth Factor Dorsal Horn Lumbar Spinal Cord Nerve Density Neonatal Administration
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