Advertisement

Acute Effects of Gangliosides on CNS Injury

  • Stephen E. Karpiak
  • Yu Shu Li
  • Paul Aceto
  • Sahebarao P. Mahadik
Part of the FIDIA Research Series book series (FIDIA, volume 6)

Abstract

Recently investigators have focused their research efforts on exogenous ganglioside effects on processes associated with CNS injury. These CNS studies were prompted by reports that ganglioside-treatments enhance peripheral nerve regeneration after damage (Gorio et al., 1981; 1983), and that when gangliosides are added to some cell or tissue cultures, increased neurite outgrowth occurs (Ferrari et al., 1983; Leon et al., 1982; Roisen et al., 1981).

Keywords

ATPase Activity Rotational Behavior Peripheral Nerve Regeneration Asymmetric Rotation Increase Neurite Outgrowth 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

CNS

central nervous system

AChE

acetylcholine esterase

AGF2

inner ester of ganglioside GM1.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Aldinio C, Valenti G, Savoini G, Kirschner GE, Agnati LF, Toffano G ( 1984 Int J Dev Neurosci 2: 267–275.CrossRefGoogle Scholar
  2. Atterwill CK, Cunningham VJ, Balazs R (1984) J Neurochem 43: 8–18.PubMedCrossRefGoogle Scholar
  3. Averit N, Rigoulet M, Cohadon F (1984) J Neurochem 42: 275–277.CrossRefGoogle Scholar
  4. Eibl H and Lands W (1969) Anal Biochem 30: 51–57.PubMedCrossRefGoogle Scholar
  5. Fass B and Ramirez J (1984) J Neurosci Res 12: 445–458.PubMedCrossRefGoogle Scholar
  6. Ferrari G, Fabris M, Gorio A (1983) Dev Brain Res 8: 215–221.CrossRefGoogle Scholar
  7. Gorio A, Carmignoto G, Facci L, Finesso M (1980) Brain Res 197: 236–241.PubMedCrossRefGoogle Scholar
  8. Gorio A, Marini P, Zanoni R (1983) Neurosci 8: 417–429.CrossRefGoogle Scholar
  9. Janigro D, Di Gregorio F, Vyskocil F, Gorio A (1984) J Neurosci Res 12: 499–509.PubMedCrossRefGoogle Scholar
  10. Karpiak SE (1983) Exp Neurol 81: 330–339.PubMedCrossRefGoogle Scholar
  11. Karpiak SE (1984) in: Ledeen RW, Yu RK, Rapport MM, Suzuki S (eds): Ganglioside Structure, Function and Biomedical Potential. Plenum Press, New York, pp. 489–497.CrossRefGoogle Scholar
  12. Karpiak SE and Mahadik SP (1984) J Neurosci Res 12: 485–492.PubMedCrossRefGoogle Scholar
  13. Karpiak SE, Mahadik SP (1985) in: Dreyfus H, Massarelli R, Freysz L and Rebel G (eds): Cellular and Pathological Aspects of Glycoconjugate Metabolism. Inserm 126: 585–598.Google Scholar
  14. Leon A, Toffano G, Sonnino S, Tettamanti G (1981) J Neurochem 37: 350–357.PubMedCrossRefGoogle Scholar
  15. Leon A, Facci L, Benvegnu D, Toffano G (1982) Dev Neurosci 5: 108–114.PubMedCrossRefGoogle Scholar
  16. Levine S and Pavan H (1966) Exp Neurol 16: 255–262.PubMedCrossRefGoogle Scholar
  17. Levine S and Sohn D (1969) Acta Pathol (Chicago) 87: 315–317.Google Scholar
  18. Li Y, Mahadik SP, Rapport MM, Karpiak SE (1986) Brain Res 377: 292–297.PubMedCrossRefGoogle Scholar
  19. Mahadik SP, Korenovsky A, Karpiak SE (1985) Abst Am Soc Neurochem 16: 231.Google Scholar
  20. Ramirez JJ, Karpiak SE, Kilfoil T, Henschel B, Grones W (1985) Soc Neurosci Abstr 11: 251.Google Scholar
  21. Roisen FJ, Bartfeld H, Nagele R, Yorke G (1981) Science 214: 577–578.PubMedCrossRefGoogle Scholar
  22. Sabel BA, Dunbar GL, Stein DG (1984a) J Neurosci Res 12: 429–443.PubMedCrossRefGoogle Scholar
  23. Sabel B, Slavin MD, Stein DG (1984b) Science 225: 340–342.PubMedCrossRefGoogle Scholar
  24. Toffano G, savoini G, Moroni F, Lombardi G, Calza L, Agnati LF (1983) Brain Res 261: 163–166.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • Stephen E. Karpiak
    • 1
  • Yu Shu Li
    • 1
  • Paul Aceto
    • 1
  • Sahebarao P. Mahadik
    • 2
  1. 1.Division of NeuroscienceNew York State Phychiatric Institute, Departments of PsychiatryUSA
  2. 2.Biochemistry and Molecular Biophysics, College of Physicians & SurgeonsColumbia UniversityNew YorkUSA

Personalised recommendations