New Evidence for the Morphofunctional Recovery of Striatal Function by Ganglioside GM1 Treatment Following a Partial Hemitransection of Rats. Studies on Dopamine Neurons and Protein Phosphorylation

  • Kjell Fuxe
  • Luigi F. Agnati
  • Fabio Benfenati
  • Isabella Zini
  • G. Gavioli
  • G. Toffano
Part of the FIDIA Research Series book series (FIDIA, volume 6)


In previous studies it has been shown that chronic treatment with GM1 can increase the survival of dopamine (DA) cell bodies with their dendrites in substantia nigra following a partial unilateral hemitransection of rats (Agnati et al., 1983a; 1984; Fuxe and Agnati, 1984; Toffano et al., 1983; 1984a). This in turn may be responsible for the enhancement of collateral sprouting observed from remaining striatal DA nerve terminals, leading to recovery of dopaminergic synaptic function in the striatum. This action has been found to be specific and not related to antiinflammatory effects of ganglioside GM1, since neither treatment with dexamethazone nor treatment with acetylsalicylic acid has been able to produce any trophic action on the nigral DA nerve cell bodies following a partial hemitransection in rats (Agnati et al., 1984). Recently we have also analyzed the effects of ganglioside GM1 treatment in unilateral partially hemitransected rats on striatal energy metabolism using the radioactive deoxyglycose technique and on striatal blood flow using radiolabelled iodoantipyrine as tracer (Agnati et al., 1985a). The results showed that GM1 can counteract the imbalance in striatal energy metabolism and in striatal blood flow found between the striatum of the lesioned and unlesioned side. This action may be related to excitatory effects of GM1 on the lesioned side and to inhibitory effects of GM1 on the unlesioned side. These results underline the evidence obtained in previous functional studies indicating that the metabolism of a striatum undergoing degenerative and regenerative changes can be at least partially restored following chronic GM1 treatment (Agnati et al., 1985a).


Ventral Tegmental Area Nerve Cell Body Lesion Side Intact Side Tyrosine Hydroxylase Inhibition 





αmethyl-p-dl-tyrosine methyl ester

cyclic AMP

cyclic adenylic acid


sodium dodecyl sulphate CCK


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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • Kjell Fuxe
    • 1
  • Luigi F. Agnati
    • 2
  • Fabio Benfenati
    • 2
  • Isabella Zini
    • 2
  • G. Gavioli
    • 2
  • G. Toffano
    • 3
  1. 1.Department of HistologyKarolinska InstitutetStockholmSweden
  2. 2.Department of Human PhysiologyUniversity of ModenaModenaItaly
  3. 3.Fidia Research LaboratoriesAbano Terme, PadovaItaly

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