The Role of Gangliosides in Neurotrophic Interaction in Vitro
Gangliosides are membrane-associated acidic glycolipids that have been implicated in the regulation of cell processes such as differentiation (Moskol et al., 1974; Roisen et al., 1981a, b; Dimpfel et al., 1981; Leon et al., 1982), growth (Fishman et al., 1977; Langenback and Kennedy, 1978; Morgan and Seifert, 1979) and axonal regeneration (Obata et al., 1977; Caccia et al., 1979; Norido et al., 1982; Spirman et al., 1982). Their concentration in the brain is 14 times higher than in liver and nearly 60 times higher than in muscle (Seyfried et al., 1978; Leeden and Yu, 1982). Patterns of ganglioside synthesis have been reported to change during intense periods of neuritogenesis and synaptogenesis (Rösner, 1980; Sonnino et al., 1981). Their abundance, distribution and temporal occurrence in neuronal membranes suggest that gangliosides play a key role in the development of the nervous system.
KeywordsNerve Growth Factor Dorsal Root Ganglion Neurite Length Nerve Growth Factor Receptor Nerve Growth Factor Treatment
bovine brain gangliosides
dorsal root ganglia
nerve growth factor
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