Advances in Ganglioside Chemistry

  • Sandro Sonnino
  • Domenico Acquotti
  • Günther Kirschner
  • Giovanni Fronza
  • Guido Tettamanti
Part of the FIDIA Research Series book series (FIDIA, volume 6)


Gangliosides, sialic acid containing glycosphingolipids, are normal components of the plasma membrane of vertebrate cells and are particularly abundant in the nervous system. They are constituted of a hydrophilic portion, the negatively charged oligosaccharide, and a hydrophobic portion, the ceramide (N-acylated long chain base), linked together by a glycosidic linkage (Ledeen and Yu, 1978; Wiegandt, 1982). The hydrophilic portion is oriented towards the extracellular environment and is assumed to be involved in recognition phenomena mediated by specific interactions between the oligosaccharide moiety and the external ligand (Brady and Fishman, 1979; Holmgren et al., 1980). The hydrophobic portion is inserted into the lipid layer of the membrane and might participate in the process of signal transduction through the membrane (Brady and Fishman, 1979).


Sialic Acid Specific Radioactivity Redistilled Water Chain Base Oligosaccharide Moiety 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



neuraminic acid


long chain base




deuterated dimethylsulfoxide


electron spin resonance


nuclear magnetic resonance


egg phosphatidylcholine


small unilamellar vesicles


critical micellar concentration


gas liquid chromatography-mass spectrometry


fast atom bombardment-mass spectrometry.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • Sandro Sonnino
    • 1
  • Domenico Acquotti
    • 1
  • Günther Kirschner
    • 2
  • Giovanni Fronza
    • 3
  • Guido Tettamanti
    • 1
  1. 1.Study Center for the Functional Biochemistry of Brain Lipids, Department of Biological Chemistry, The Medical SchoolUniversity of MilanMilanoItaly
  2. 2.Department of ChemistryFIDIA Research LaboratoriesAbano TermeItaly
  3. 3.CNR Study Center for Natural Organic Substances, Department of ChemistryPolytechnic School of MilanMilanoItaly

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