Metabolism of Exogenous GM1 and Related Glycolipids in the Rat
Knowledge of the fate and metabolic pathways run by gangliosides administered to animals is interesting from both the pharmacological and biochemical points of view. Ceccarelli et al. (1976) and Obata et al. (1977) first discovered that exogenous gangliosides facilitate development of neuromuscular junctions in in vivo and in vitro systems. Since then many reports definitely established the ability of exogenous gangliosides to induce the formation of neurite-like processes in a number of neural cells cultivated in vitro, and to facilitate functional recovery of damaged peripheral and central nervous system by promoting neuronal survival, nerve regeneration and rein-nervation (for review see Ledeen, 1985). The molecular mechanisms underlying these effects are unknown and possibly connected with the physiological performances of the endogenous gangliosides.
KeywordsGolgi Apparatus Tritiated Water Chain Base Brain Ganglioside Neutral Glycolipid
dichloro-diciano benzo quinone
high performance liquid chromatography
ethylene diamino tetracetic acid
thin layer chromatography.
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