Axonal Transport of Gangliosides and Neutral Glycolipids in the Peripheral Nervous System. Identification of Ganglioside Types in Motoneurons of the PNS
The highly compartmentalized nature of ganglioside biosynthesis in cells (Yusef et al., 1983) together with their widespread distribution over the cell surface (Ledeen, 1978) has suggested the presence of efficient transport/transfer mechanisms. One aspect of these processes has been elucidated in the central nervous system (CNS) through demostration of fast axonal transport as the primary mechanism for conveyance of gangliosides to axonal and nerve-ending membranes (Forman and Ledeen, 1972; Rosner et al., 1973; Landa et al., 1979; Ledeen et al., 1981; Gammon et al., 1985). Recent studies with sciatic nerve of rabbit (Yates et al., 1984) and rat (Aquino et al., 1985a) have demonstrated similar anterograde flow of gangliosides in the PNS as well. The above rat system, involving motoneurons, also revealed another aspect of ganglioside movement in the neuron, i.e., retrograde axonal transport.
KeywordsSciatic Nerve Axonal Transport Retrograde Transport Sensory Axon Fast Axonal Transport
central nervous system
peripheral nervous system
dorsal root ganglia
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