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Antibody to Glycolipid in a Patient with IgM Paraproteinemia and Polyradiculoneuropathy

  • Hiroko Baba
  • Nobuyuki Miyatani
  • Shuzo Sato
  • Kyoko Nakamura
  • Tatsuhiko Yuasa
  • Tadashi Miyatake
Part of the FIDIA Research Series book series (FIDIA, volume 6)

Abstract

Although peripheral neuropathy is a well-known complication of myeloma and other paraproteinemias, it has been uncertain whether these paraproteins play a primary role in the pathogenesis of neuropathy or not. Recently Braun et al. (1982) demonstrated that IgM monoclonal antibodies from patients with IgM paraproteinemia and polyneuropathy reacted with myelin-associated glycoprotein (MAG). Ilyas et al. (1984) reported that IgM from some of these patients reacted with both MAG and an acidic glycolipid in human peripheral nerve ganglioside fraction, and suggested that a carbohydrate determinant which reacted with these patients’ IgM was shared between MAG and this acidic glycolipid. We reported previously (Baba et al., 1985) a patient with IgM paraproteinemia and polyradiculoneuropathy whose serum only reacted with a lipid component in human peripheral nerve ganglioside fraction but not with MAG. We demonstrate here further studies on this glycolipid.

Keywords

Intraneural Injection Human Peripheral Nerve Acidic Glycolipid Orcinol Reagent Crude Ganglioside 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

MAG

myelin associated glycoprotein

SDS

sodium dodecylsulphate

PAP

peroxidase antiperoxidase

BSA

bovine serum albumin

DAB

diaminobenzidine

TLC

thin layer chromatography

SLPG

sialosyllactosaminyl paragloboside.

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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • Hiroko Baba
    • 1
  • Nobuyuki Miyatani
    • 1
  • Shuzo Sato
    • 1
  • Kyoko Nakamura
    • 1
    • 2
  • Tatsuhiko Yuasa
    • 1
  • Tadashi Miyatake
    • 1
  1. 1.Department of Neurology, Brain Research InstituteNiigata UniversityAsahimachi-dori, Niigata 951Japan
  2. 2.Department of Biochemistry and MetabolismThe Tokyo Metropolitan Institute of Medical ScienceTokyoJapan

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