Involvement of Gangliosides in the Synaptic Transmission in the Hippocampus and Striatum of the Rat Brain

  • A. Wieraszko
  • W. Seifert
Part of the FIDIA Research Series book series (FIDIA, volume 6)


For a long time it has been suggested that gangliosides can somehow modulate synaptic transmission (Svennerholm, 1980; Rahmann, 1983). However, the experimental proof is still missing. It was demonstrated over 20 years ago that gangliosides help neuronal tissue to recover from the transient exposure to cold (Balakrishman and McIlwain, 1961; McIlwain, 1961). In the last 10 years functional studies on gangliosides concentrated mainly on the neurotrophic effects of gangliosides in nerve cell cultures (Morgan and Seifert, 1979; Seifert, 1981) and on the potential influence of gangliosides on the reinnervation processes in the nervous system (Ledeen, 1984). Surprisingly, very little effort has been made to test the hypothesis put forward for the first time by Svennerholm (1963, 1980) and later in more detailed form by Rahmann et al. (1976) concerning participation of gangliosides in neurotransmission. Our study is addressed directly to this problem.


Sialic Acid Pyramidal Neuron Hippocampal Slice Cholera Toxin Population Spike 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Neuraminidase from Vibrio Cholerae


Neuraminidase from Arthrobacter Ureafaciens


Ruthenium Red


Cholera Toxin


Tetanus Toxin


Antiserum against ganglioside GM1




Long Term Potentiation.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • A. Wieraszko
    • 1
  • W. Seifert
    • 1
  1. 1.Department of Neurobiology, Laboratory of Molecular NeurobiologyMax-Planck-Institute für biophysikalische ChemieGöttingenFederal Republic of Germany

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