Abstract
Dietary prevention is believed to be the most promising means by which incidence and recurrence of cancer can be reduced as evidenced by numerous epidemiologic studies (Hill, 1995). Flavonoids are known to inhibit cancer and heart disease as suggested by numerous cell, animal and human studies (Middleton and Kandaswami, 1994b; Das, 1990; Weisburger, 1992; Huang and Ferraro, 1992; Wattenberg, 1982; Hertog et al., 1995). Although reported to have beneficial health effects (Middleton and Kandaswami, 1994a) two subclasses of flavonoids, namely flavanones occurring abundantly in citrus fruits (Mouly et al., 1993) and (+)-catechins occurring in large amounts in pit fruits and green and black tea (Graham, 1992), emerge to be studied recently regarding their anti cancer effects (Cody et al., 1988). Most previously performed studies considered exclusively late stages of carcinogenesis such as tumor growth or invasion phenomena (Bracke et al., 1991; Kandaswami et al., 1991) and research on tea compounds considered either crude tea extracts or gallo-catechins (Mukhtar et al., 1992; Stich, 1992). Prevention of cancer by the flavonoid hesperidin or by the flavanone (+)-catechin at early stages of carcinogenesis and availability of these agents particularly on the cellular level are little investigated.
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Franke, A.A., Custer, L.J., Cooney, R.V., Tanaka, Y., Xu, M., Dashwood, R.H. (2002). Inhibition of Colonic Aberrant Crypt Formation by the Dietary Flavonoids (+)-Catechin and Hesperidin. In: Buslig, B.S., Manthey, J.A. (eds) Flavonoids in Cell Function. Advances in Experimental Medicine and Biology, vol 505. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5235-9_11
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DOI: https://doi.org/10.1007/978-1-4757-5235-9_11
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