Inhibition of Colonic Aberrant Crypt Formation by the Dietary Flavonoids (+)-Catechin and Hesperidin

  • Adrian A. Franke
  • Laurie J. Custer
  • Robert V. Cooney
  • Yuichiro Tanaka
  • Meirong Xu
  • Roderick H. Dashwood
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 505)


Dietary prevention is believed to be the most promising means by which incidence and recurrence of cancer can be reduced as evidenced by numerous epidemiologic studies (Hill, 1995). Flavonoids are known to inhibit cancer and heart disease as suggested by numerous cell, animal and human studies (Middleton and Kandaswami, 1994b; Das, 1990; Weisburger, 1992; Huang and Ferraro, 1992; Wattenberg, 1982; Hertog et al., 1995). Although reported to have beneficial health effects (Middleton and Kandaswami, 1994a) two subclasses of flavonoids, namely flavanones occurring abundantly in citrus fruits (Mouly et al., 1993) and (+)-catechins occurring in large amounts in pit fruits and green and black tea (Graham, 1992), emerge to be studied recently regarding their anti cancer effects (Cody et al., 1988). Most previously performed studies considered exclusively late stages of carcinogenesis such as tumor growth or invasion phenomena (Bracke et al., 1991; Kandaswami et al., 1991) and research on tea compounds considered either crude tea extracts or gallo-catechins (Mukhtar et al., 1992; Stich, 1992). Prevention of cancer by the flavonoid hesperidin or by the flavanone (+)-catechin at early stages of carcinogenesis and availability of these agents particularly on the cellular level are little investigated.


Orange Juice Aberrant Crypt Focus Heterocyclic Amine Dietary Flavonoid Transformation Assay 
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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Adrian A. Franke
    • 1
  • Laurie J. Custer
    • 1
  • Robert V. Cooney
    • 1
  • Yuichiro Tanaka
    • 1
  • Meirong Xu
    • 2
  • Roderick H. Dashwood
    • 2
  1. 1.Cancer Research Center of HawaiiHonoluluUSA
  2. 2.The Linus Pauling Institute, Environmental and Molecular ToxicologyOregon State UniversityCorvallisUSA

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