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Immobilized Enzymes in Tubes and Hollow Fibers for Clinical Applications

  • H. Pedersen
  • C. Horvath
  • J. R. Bertino

Abstract

When soluble enzymes are used in therapy it is usually necessary to administer a relatively large amount of the enzyme in order to maintain an adequate catalytic activity in the circulating blood for a sufficiently long time. As a result of repeated administration, however, the foreign protein often causes potentially serious untoward immunological effects in the host, and therapy must be stopped. Consequently, the value of such a therapeutic approach is seriously reduced.

Keywords

Immobilize Enzyme Hollow Fiber Fiber Wall Amino Acid Restriction Porous Shell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1978

Authors and Affiliations

  • H. Pedersen
    • 1
  • C. Horvath
    • 1
  • J. R. Bertino
    • 1
  1. 1.Department of Engineering and Applied Science and Departments of Pharmacology and Medicine School of MedicineYale UniversityNew HavenUSA

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