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Refixation of Solubilized and Purified Microsomal Enzymes: Towards an Extracorporal Detoxification in Liver Failure

  • G. Brunner
  • H. Lösgen

Abstract

Few attempts have been made to solubilize and purify membrane bound enzymes with the aim of refixation to artificial carriers. The main reason is that after solubilization membrane bound enzymes are often less stable due to a loss of natural environment or cofactors and consequently do not allow lengthy steps of purification.

Keywords

Liver Failure Microsomal Enzyme Microsomal Membrane Hydroxylation Activity Multienzyme Complex 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1978

Authors and Affiliations

  • G. Brunner
    • 1
  • H. Lösgen
    • 1
  1. 1.Department of Gastroenterology and Metabolic DiseasesUniversity of GottingenW. Germany

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