Mass Transfer and Reaction with Microcapsules Containing Enzyme and Adsorbent
Microencapsulation has been used to immobilize enzymes acting on low molecular weight substrates. This is particularly useful in the field of medicine since the enzyme enveloped in an ultra-thin membrane may avoid adverse allergic and immunological reactions which would otherwise be induced by administration of the enzyme solution directly into the body. One promising medical application is the capsular artificial kidney where urea, which is not well adsorbed to any available adsorbent, is decomposed by encapsulated urease (1–3). Estimates have been made as to how compact this capsular artificial kidney might be (4).
Unable to display preview. Download preview PDF.
- 1.CHANG, T.M.S. “Artificial Cells”, Charles C. Thomas, Springfield, Ill., 1972.Google Scholar
- 2.SPARKS, R.E., SALEMME, R.M., MEIER, P.M., LITT, M.H. LINDEN, O. Trans. Amer. Soc. Artif. Intern. Organs. 15: 353, 1969.Google Scholar
- 3.GARDNER, D.L., FALB, R.D., KIM, B.C. EMMERLING, D.C. Trans. Amer. Soc. Artif. Intern. Organs. 17: 239, 1971.Google Scholar
- 6.NAKAMURA, K. MORI. “Immobilized Enzyme Technology Research and Applications” (Ed. H.H. Weetall and S. Suzuki) Plenum Press, New York, 1975, p. 99.Google Scholar
- 7.OOTAKE, T. “Kagaku Kogaku, 3” (Textbook of Chem. Eng. Vol. 3) Iwanami Shoten, ( Iwanami Publishing Co., Tokyo ) 1963, p. 133.Google Scholar