Endotoxin pp 653-664 | Cite as

New Therapeutic Method Against Septic Shock — Removal of Endotoxin Using Extracorporeal Circulation

  • M. Kodama
  • K. Hanasawa
  • T. Tani
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 256)


Polymyxin B has been shown to prevent endotoxin-induced mortality of mice and rabbits (9, 10), and to decrease the incidence of endotoxindisseminated intravascular coagulation (1). However, its use is limited only to oral or local administration because of its strong side effect on the central nervous system and the kidneys. Therefore, it cannot be used by intravenous injection for the therapy of endotoxemia. To solve problems, a new method of preparing polymyxin B by fixing it to an insoluble fiber was developed. We previously reported that polymyxin B would be covalently coupled to an insoluble fiber and could not be removed anymore by washing with isotonic saline (1, 3).


Endotoxin Shock Insoluble Fiber Endotoxin Concentration Aortic Blood Pressure Endotoxin Infusion 
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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • M. Kodama
    • 1
  • K. Hanasawa
    • 1
  • T. Tani
    • 1
  1. 1.Department of SurgeryShiga University of Medical ScienceSeta-Tsukiwacho, Otsu, ShigaJapan

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