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Endotoxin pp 593-601 | Cite as

Alterations of Responses to Bacterial Endotoxin by Bacteroides Fragilis in Vivo and in Vitro

  • A. C. Rodloff
  • S. Ehlers
  • D. K. Blanchard
  • H. Hahn
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 256)

Abstract

Gram negative obligately anaerobic bacteria constitute a major part of the normal indigenous bacterial flora of humans, however, they also have to be considered to be important opportunistic pathogens, e.g., infections with Bacteroidaceae may arise, when the function of the mucous membranes as anato­mic barrier for microorganisms is compromised and bacteria are introduced into otherwise sterile tissues. In such instances, the resulting infection is often of polymicrobial etiology and Bacteroidaceae are found especially in association with Enterobacteriaceae. It is clinical experience that these mixed aerobic/anaerobic infections create significant therapeutical problems even if the individual causative microorganisms display a high in-vitro­susceptibility to antimicrobial agents employed. Therefore, efforts were made to study the interaction of aerobes and anaerobes in mixed infections with a number of different animal models.

Keywords

Spleen Cell Infected Mouse Listeria Monocytogenes Post Infection Bacteroides Fragilis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • A. C. Rodloff
    • 1
  • S. Ehlers
    • 1
  • D. K. Blanchard
    • 2
  • H. Hahn
    • 1
  1. 1.Institute for Medical Microbiology and ImmunologyFree University of BerlinFederal Republic of Germany
  2. 2.Department of Medical Microbiology and ImmunologyUniversity of South FloridaTampaUSA

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