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Endotoxin pp 589-591 | Cite as

Biological Properties of Lipopolysaccharides Isolated from Bordetella

  • M. Watanabe
  • H. Takimoto
  • Y. Kumazawa
  • K. Amano
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 256)

Abstract

Biological activity of lipopolysaccharides (LPSs) separated from Bordetella, i.e., B. pertussis (Bp), B. parapertussis (Bpp) and B. bronchiseptica (Bbs), was determined and compared with that of an Escherichia coli LPS as a control. Two Bp-LPS preparations showed marked biological activities comparable to those of E. coli LPS in terms of lethal toxicity in galactosaminesensitized mice, pyrogenicity in rabbits, mitogenicity in C3H/He spleen cell cultures, macrophage activation and tumor necrosis factor-inducing activity. All the activities except mitogenicity of two Bpp-LPS preparations were lower than or comparable to those of E. coli LPS. Activities stronger than or comparable to those of E. coli LPS were observed in two Bbs-LPS preparations. Among six LPS preparations from Bordetella tested, a Bbs-LPS from L3 strain exhibited the most intensive activities.

Keywords

Macrophage Activation Intensive Activity Bordetella Pertussis Lethal Toxicity Japanese White Rabbit 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • M. Watanabe
    • 1
  • H. Takimoto
    • 1
  • Y. Kumazawa
    • 2
  • K. Amano
    • 3
  1. 1.The Kitasato InstituteKitasato UniversityMinato-ku Tokyo 108Japan
  2. 2.School of Pharmaceutical SciencesKitasato UniversityMinato-ku Tokyo 108Japan
  3. 3.Hirosaki University School of MedicineHirosaki 036Japan

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