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Endotoxin pp 581-583 | Cite as

Anti-LPS Region Antibody Responses and Cellular Immune Responsiveness in Typhoid Patients

  • C. M. Mastroianni
  • A. Misefari
  • E. Jirillo
  • C. De Simone
  • V. Vullo
  • S. Delia
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 256)

Abstract

In recent years, several reports have provided evidence for an involvement of the immune system during typhoid fever (3). In particular, a reduction of several immunological parameters such as leukocyte inhibiting factor (LIF) release, plaque-forming cell (PFC) production and natural killer (NK) cell activity have been demonstrated (1). In addition, Salmonella typhi organisms possess on their outermembrane the lipopolysaccharide (LPS) which is a powerful immunomodulating agent (4). Therefore, to better investigate the relationship between immune function and typhoid fever, we analyzed humoral and cell-mediated responses in typhoid patients towards LPS or whole bacteria.

Keywords

Antibody Titer Typhoid Fever Immunological Parameter Arachidonic Acid Metabolite Human Brucellosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Antonaci, S., Garofalo, A. R., Stasi, D., Caretto, G., Jirilli, E. and Bonomo, L., 1987, Cell-mediated immunity in typhoid fever patients. Microbios Letters 35: 19.Google Scholar
  2. 2.
    Delia, S., Vullo, V., Mastroianni, C. M., Contini, C., Massetti, A. P., Cignarella, L. and Sorice, F., 1987, Use of dot immunobinding assay (DIB) for the rapid diagnosis of human brucellosis. J. Infection 14: 88.Google Scholar
  3. 3.
    Edelman, R. and Levine, M. M., 1986, Summary of an International Workshop of Typhoid Fever. Rev. Infect. Dis. 8: 329.Google Scholar
  4. 4.
    Galanos, C., Luderitz, O., Rietschel, E. T. and Westphal, 0., 1977, Newer aspects of the chemistry and biology of bacterial lipopolysaccharides, with special reference to their lipid A component, in: “International Review of Biochemistry. Biochemistry of lipids. II. Vol. 14,” T. W. Goodwin, ed., Baltimore, p. 239.Google Scholar
  5. 5.
    Tagliabue, A., Villa, L., Boraschi, D., Peri, G., De Gori, V. and Nencioni, L., 1985, Natural anti-bacterial activity against Salmonella typhi by human T4+ lymphocytes armed with IgA antibodies. J. Immunol. 135: 4178.PubMedGoogle Scholar
  6. 6.
    Vullo, V., Contini, C., Mastroianni, C. M., Massetti, A. P., Cignarella, L. and Delia, S., 1987, Evaluation of Dot Immunobinding Assay (DIB) for the Detection of Antibodies Against Brucella Melitensis, EOS Riv. Immunol. Immunopharmacol. 7: 147.Google Scholar

Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • C. M. Mastroianni
    • 1
  • A. Misefari
    • 2
  • E. Jirillo
    • 3
  • C. De Simone
    • 4
  • V. Vullo
    • 1
  • S. Delia
    • 1
  1. 1.Malattie Infettive IIIUniversitá “La Sapienza”RomaItaly
  2. 2.Cattedra di ImmunologiaUniversitá di MessinaMessinaItaly
  3. 3.Cattedra di ImmunologiaUniversitá di BariBariItaly
  4. 4.Malattie InfettiveUniversitá dell Aquila degli AbruzziL’AquilaItaly

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