Abstract
Lipopolysaccharide (LPS) is an inducer of toxic and immunostimulatory or immunoregulatory responses (2). The lipid A moiety was shown to be the endotoxic principle of LPS (3, 9). Data about immunostimulatory properties like induction of interleukin 1 (IL-1) by LPS and lipid A are still conflicting. In this report LPS and partial structures thereof were used to define the structural element of LPS which is responsible for IL-1 induction. Evidence is given that lipid A is not only the endotoxic but also the major immunostimulatory and immunoregulatory principle of LPS.
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References
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Loppnow, H. et al. (1990). Lipid A, the Immunostimulatory Principle of Lipopolysaccharides ?. In: Friedman, H., Klein, T.W., Nakano, M., Nowotny, A. (eds) Endotoxin. Advances in Experimental Medicine and Biology, vol 256. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5140-6_50
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DOI: https://doi.org/10.1007/978-1-4757-5140-6_50
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