The Mechanism of Adjuvant Action of Bacterial Lipopolysaccharide (LPS) in Subcutaneous Immunization
Bacterial lipopolysaccharide (LPS) exhibits an adjuvant action on antibody response to various antigens in mice. The adjuvant action induced by subcutaneous (s.c.) injection of LPS with antigen is different from that by intraperitoneal (i.p.) or intravenous (i.v.) injection (2). In the present study, we investigated histological changes at the regional s.c. tissues after injection with LPS and the tissue distribution of the LPS. It was suggested that there were two distinct mechanisms of adjuvant action which operated at the early and late stages after s.c. immunization, respectively.
KeywordsRegional Site Lymphoid Follicle Bacterial Lipopolysaccharide Adjuvant Action Phenol Water
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