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Endotoxin pp 549–556Cite as

The Mediation of Endotoxin-Induced Beneficial Effects by Cytokines

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 256))

Abstract

Endotoxins, when entering the circulation in sufficient amounts, elicit multiple effects that can lead to shock and death. Besides these detrimental effects, endotoxins in minute concentrations may nonspecifically contribute to regulate the steady state of host defense. Moreover, various experimental approaches have shown, already in the early years of endotoxin research, that injection of small amounts of extracted endotoxins can induce beneficial effects, such as tolerance to the pyrogenic and lethal effects of endotoxin, nonspecific resistance to microbial infections and irradiation disease, stimulation of hematopoiesis, as well as tumor regression. These beneficial effects of endotoxins have been reviewed recently (13).

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Author information

Authors and Affiliations

  1. Department of Immunology and Serology, Institute of Medical Microbiology and Hygiene, Klinikum Mannheim, University of Heidelberg, D6, 5, 6800, Mannheim, Germany

    R. Urbaschek & B. Urbaschek

Authors
  1. R. Urbaschek
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  2. B. Urbaschek
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Editor information

Editors and Affiliations

  1. The University of South Florida, Tampa, Florida, USA

    Herman Friedman  & T. W. Klein  & 

  2. Jichi Medical School, Tochigi-Ken, Japan

    Masayasu Nakano

  3. University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Alois Nowotny

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© 1990 Springer Science+Business Media New York

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Urbaschek, R., Urbaschek, B. (1990). The Mediation of Endotoxin-Induced Beneficial Effects by Cytokines. In: Friedman, H., Klein, T.W., Nakano, M., Nowotny, A. (eds) Endotoxin. Advances in Experimental Medicine and Biology, vol 256. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5140-6_48

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  • DOI: https://doi.org/10.1007/978-1-4757-5140-6_48

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-5142-0

  • Online ISBN: 978-1-4757-5140-6

  • eBook Packages: Springer Book Archive

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